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Titolo:
African-American heredity prostate cancer study: A model for genetic research
Autore:
Powell, IJ; Carpten, J; Dunston, G; Kittles, R; Bennett, J; Hoke, G; Pettaway, C; Weinrich, S; Vijayakumar, S; Ahaghotu, CA; Boykin, W; Mason, T; Royal, C; Baffoe-Bonnie, A; Bailey-Wilson, J; Berg, K; Trent, J; Collins, F;
Indirizzi:
Wayne State Univ, Dept Urol, Karmanos Canc Inst, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 os Canc Inst, Detroit, MI 48201 USA
Titolo Testata:
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
fascicolo: 4, volume: 93, anno: 2001,
pagine: 120 - 123
SICI:
0027-9684(200104)93:4<120:AHPCSA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSCEPTIBILITY LOCUS; HIGH-RISK; CHROMOSOME; FAMILIES;
Keywords:
prostate cancer; genetics; ethnicity; oncology; human genome project;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Powell, IJ Wayne State Univ, Dept Urol, Karmanos Canc Inst, 4160 John R,Ste 1017, Detroit, MI 48201 USA Wayne State Univ 4160 John R,Ste 1017 DetroitMI USA 48201 USA
Citazione:
I.J. Powell et al., "African-American heredity prostate cancer study: A model for genetic research", J NAT MED A, 93(4), 2001, pp. 120-123

Abstract

A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome Iq (HPC1). Aneven greater proportion of African-American families have shown linkage toHPC1. Therefore, investigators at the National Human Genome Research institute (NHGR1) in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples fromrecruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGR1 at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:58:18