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Titolo:
Bone mass and breast cancer risk in older women: Differences by stage at diagnosis
Autore:
Zmuda, JM; Cauley, JA; Ljung, BM; Bauer, DC; Cummings, SR; Kuller, LH;
Indirizzi:
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF THE NATIONAL CANCER INSTITUTE
fascicolo: 12, volume: 93, anno: 2001,
pagine: 930 - 936
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINERAL DENSITY; OSTEOPOROTIC FRACTURES; POSTMENOPAUSAL WOMEN; INHIBIT GROWTH; HORMONE LEVELS; ELDERLY WOMEN; TNF-ALPHA; ESTROGEN; WEIGHT; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Zmuda, JM Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, 130 DeSoto St, Pittsburgh, PA 15261 USA Univ Pittsburgh 130 DeSoto St Pittsburgh PA USA 15261 15261 USA
Citazione:
J.M. Zmuda et al., "Bone mass and breast cancer risk in older women: Differences by stage at diagnosis", J NAT CANC, 93(12), 2001, pp. 930-936

Abstract

Background: Cider women with low bone mineral density (BMD) have a decreased incidence of breast cancer. It is not known whether this association is confined to early-stage, slow-growing tumors. Methods: We prospectively studied 8905 women who were 65 years of age or older during the period from 1986 through 1988 and had no history of breast cancer. At study entry, we used single-photon absorptiometry to measure each woman's BMD at three skeletal sites: the wrist, forearm, and heel. The women were followed for a mean of 6.5 years for the occurrence of breast cancer. All statistical tests weretwo-sided. Results: During 57516 person-years of follow-up, 315 women developed primary invasive or in situ breast cancer. Multivariate analyses thatadjusted for age, obesity, and other covariates revealed that the risk of breast cancer for nomen in the highest quartile of BMD for all three skeletal sites was 2.1 (95% confidence interval [CI] = 1.4 to 5.3) times greater than that for women in the lowest quartile at all three skeletal sites. Themagnitude of increased risk associated with high BMD differed by the stageof disease at diagnosis and was greater for more advanced tumors (relativerisk [RR] for TNM [i.e., tumor-lymph node-metastasis] stage II or higher tumors = 5.6; 95% CI = 1.2 to 27.4) than for early-stage disease (RR for in situ/TNM stage I tumors = 2.2; 95% CI = 1.0 to 4.8). Conclusions: Elderly women with high BMD have an increased risk of breast cancer, especially advanced cancer, compared with women with low BMD. These findings suggest an association between osteoporosis and invasive breast cancer, two of the most prevalent conditions affecting an older woman's health.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:49:31