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Titolo:
Myocardial flow reserve in patients with a systemic right ventricle after atrial switch repair
Autore:
Singh, TP; Humes, RA; Muzik, O; Kottamasu, S; Karpawich, PP; Di Carli, MF;
Indirizzi:
Wayne State Univ, Sch Med, Dept Pediat, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 Dept Pediat, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Dept Internal Med, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 Internal Med, Detroit, MI 48201 USA Wayne State Univ, Sch Med, Dept Radiol, Detroit, MI USA Wayne State Univ Detroit MI USA v, Sch Med, Dept Radiol, Detroit, MI USA Childrens Hosp Michigan, PET Ctr, Detroit, MI 48201 USA Childrens Hosp Michigan Detroit MI USA 48201 T Ctr, Detroit, MI 48201 USA
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 8, volume: 37, anno: 2001,
pagine: 2120 - 2125
SICI:
0735-1097(20010615)37:8<2120:MFRIPW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; BLOOD-FLOW; GREAT-ARTERIES; MUSTARD OPERATION; N-13 AMMONIA; CORONARY CIRCULATION; INTACT DOGS; EXERCISE; HYPERTROPHY; TRANSPOSITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, TP Childrens Hosp Michigan, Div Cardiol, 3901 Beaubien Blvd, Detroit, MI 48111 USA Childrens Hosp Michigan 3901 Beaubien Blvd Detroit MI USA 48111
Citazione:
T.P. Singh et al., "Myocardial flow reserve in patients with a systemic right ventricle after atrial switch repair", J AM COL C, 37(8), 2001, pp. 2120-2125

Abstract

OBJECTIVES The purpose of this study was to assess myocardial blood flow (MBF) and flow reserve in systemic right ventricles (RV) in long-term survivors of the Mustard operation. BACKGROUND There is a high prevalence of systemic RV dysfunction and impaired exercise performance in long-term survivors of the Mustard operation. Amismatch between myocardial blood supply and systemic ventricular work demand has been proposed as a potential mechanism. METHODS We assessed MBF at rest and during intravenous adenosine hyperemiain 11 long-term survivors of a Mustard repair (age 18 +/- 5 years, median age at repair 0.7 years, follow-up after repair 17 +/- 5 years) and 13 healthy control subjects (age 23 +/- 7 years), using N-13 ammonia and positron emission tomography imaging. RESULTSThere was no difference in basal MBF between the systemic RV of survivors of the Mustard operation and the systemic left ventricle (LV) of healthy control subjects (0.80 +/- 0.19 vs. 0.74 +/- 0.15 ml/g/min, respectively, p = NS). However, the hyperemic flows were significantly lower in systemic RVs than they were in systemic LVs (2.34 +/- 0.0.69 vs. 3.44 +/- 0.62 ml/g/min respectively, p < 0.01). As a result, myocardial flow reserve was lower in systemic RVs than it was in systemic LVs (2.93 <plus/minus> 0.63 vs. 4.74 +/- 1.09, respectively, p < 0.01). CONCLUSIONS Myocardial flow reserve is impaired in systemic RVs in survivors of the Mustard operation. This may contribute to systemic ventricular dysfunction in these patients. (J Am Coll Cardiol 2001;37:2120-5) (C) 2001 bythe American College of Cardiology.

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Documento generato il 18/01/20 alle ore 14:01:07