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Titolo:
Recent advances in the clinical application of aromatase inhibitors
Autore:
Harper-Wynne, C; Dowsett, M;
Indirizzi:
Royal Marsden Hosp, Acad Dept Biochem, London SW3 3JJ, England Royal Marsden Hosp London England SW3 3JJ ochem, London SW3 3JJ, England
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 1-5, volume: 76, anno: 2001,
pagine: 179 - 186
SICI:
0960-0760(200101/03)76:1-5<179:RAITCA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED BREAST-CANCER; BONE-MINERAL DENSITY; PLASMA ESTROGEN-LEVELS; POSTMENOPAUSAL WOMEN; MEGESTROL-ACETATE; RANDOMIZED TRIAL; DOUBLE-BLIND; ANASTROZOLE ARIMIDEX; HORMONAL TREATMENT; TAMOXIFEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Harper-Wynne, C Royal Marsden Hosp, Acad Dept Biochem, Fulham Rd, London SW3 3JJ, England Royal Marsden Hosp Fulham Rd London England SW3 3JJ gland
Citazione:
C. Harper-Wynne e M. Dowsett, "Recent advances in the clinical application of aromatase inhibitors", J STEROID B, 76(1-5), 2001, pp. 179-186

Abstract

Aromatase inhibitors have evolved over a period of 20 years to well tolerated agents that can effectively obliterate aromatase activity in postmenopausal women. Breast cancer is the predominant clinical application and here the newer agents have established themselves as the preferred second-line agent after tamoxifen in the treatment of advanced disease. Recent data indicate that they be more efficacious than tamoxifen and, therefore, may replace it as the first-line agent of choice in the near future. On-going clinical trials in the adjuvant setting and prospective prevention studies will elucidate whether these drugs have a yet greater role in breast cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:17:15