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Titolo:
Resistance to multiple steroids in two sisters
Autore:
New, MI; Nimkarn, S; Brandon, DD; Cunningham-Rundles, S; Wilson, RC; Newfield, RS; Vandermeulen, J; Barron, N; Russo, C; Loriaux, DL; OMalley, B;
Indirizzi:
Cornell Univ, New York Presbyterian Hosp, Weill Med Coll, Dept Pediat,Div Pediat Endocrinol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 iat Endocrinol, New York, NY 10021 USA Oregon Hlth Sci Univ, Dept Med, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 pt Med, Portland, OR 97201 USA McMaster Univ, Dept Pediat, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada Univ, Dept Pediat, Hamilton, ON, Canada Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ept Cell Biol, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 1-5, volume: 76, anno: 2001,
pagine: 161 - 166
SICI:
0960-0760(200101/03)76:1-5<161:RTMSIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY CORTISOL RESISTANCE; GLUCOCORTICOID RECEPTOR; SQUIRREL-MONKEY; TRANSCRIPTIONAL COACTIVATOR; HORMONE RESISTANCE; NUCLEAR RECEPTORS; PROGESTERONE; ACTIVATION; GENE; SUPERFAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: New, MI Cornell Univ, New York Presbyterian Hosp, Weill Med Coll, Dept Pediat,Div Pediat Endocrinol, 525 E 68th St,Room M-622, New York, NY 10021 USACornell Univ 525 E 68th St,Room M-622 New York NY USA 10021 21 USA
Citazione:
M.I. New et al., "Resistance to multiple steroids in two sisters", J STEROID B, 76(1-5), 2001, pp. 161-166

Abstract

A 14-year-old Native American girl from the Iroquois Nation was referred as a potential patient with the syndrome of Apparent Mineralocorticoid Excess. Instead, her evaluation revealed resistance to glucocorticoids, mineralocorticoids, and androgens. She lacked Cushingoid features in spite of significantly high cortisol levels, Menstruation was regular and there was no clinical evidence of masculinization despite high serum androgen levels in the male range. The patient's sister had similar clinical features. Partial resistance to exogenous glucocorticoid and mineralocorticoid administration was well demonstrated in both patients. It is proposed that these patients represent the first cases of partial resistance to multiple steroids, possibly owing to a coactivator defect. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:53:28