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Titolo:
Kinetics and characterization of cellular responses in the peritoneal cavity of mice infected with Taenia crassiceps
Autore:
Padilla, A; Govezensky, T; Sciutto, E; Jimenez-Garcia, LF; Gonsebatt, ME; Ramirez, P; Larralde, C;
Indirizzi:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico
Titolo Testata:
JOURNAL OF PARASITOLOGY
fascicolo: 3, volume: 87, anno: 2001,
pagine: 591 - 599
SICI:
0022-3395(200106)87:3<591:KACOCR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE CYSTICERCOSIS; CEREBROSPINAL-FLUID; IMMUNE-RESPONSE; ANTIGENS; SOLIUM; PATHOGENESIS; METACESTODE; RESISTANCE; MECHANISM; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Larralde, C Univ Nacl Autonoma Mexico, Inst Invest Biomed, AP 70228, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico AP 70228 Mexico City DF Mexico 04510
Citazione:
A. Padilla et al., "Kinetics and characterization of cellular responses in the peritoneal cavity of mice infected with Taenia crassiceps", J PARASITOL, 87(3), 2001, pp. 591-599

Abstract

Changes in the leukocyte population of the peritoneal cavity ensue immediately after infection with Taenia crassiceps metacestodes. Basophils and neutrophils decrease, whereas macrophages, monocytes, and lymphocytes increaseto reach only modest levels by 6 wk and then diminish to nearly disappear by 15 wk when the parasite begins rapid reproduction. Eosinophils also appear early in infection, but then abate to lower levels that persist. In lateinfections, when the mass of cysticerci equals that of the mouse, the cysticerci grow among surprisingly few inflammatory cells. Mingling with the peritoneal inflammatory cells is a number of odd-looking cells that could correspond to the metaplasic mesothelial cells of the host or be of parasite origin. These cells are multinucleated, they aggregate in varigerated clusters, and form cystic structures in vitro; they also bind specific anti-T. crassiceps antibodies and specific T. crassiceps DNA probes in their nuclei. When the peritoneal cell exudate is reinjected intraperitoneally into naivemice, the odd-looking cells subsist for months, inducing in the host the synthesis of specific anti-ir. crassiceps antibodies and immune resistance to challenge but do not reassemble into cysticerci even after 6 mo of inoculation. The early appearance and the immunogenic and antigenic properties ofthese odd-looking cells suggest they are important protagonists in the early host-parasite confrontation when the outcome of infection is set.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:13:45