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Titolo:
Evaluation of a stereotactic frame for repositioning of the rat brain in serial positron emission tomography imaging studies
Autore:
Rubins, DJ; Meadors, AK; Yee, S; Melega, WP; Cherry, SR;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Crump Inst Mol Imaging, Dept Mol & Med Pharmacol, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA Pharmacol, Los Angeles, CA USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 1-2, volume: 107, anno: 2001,
pagine: 63 - 70
SICI:
0165-0270(20010530)107:1-2<63:EOASFF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL ACTIVATION; SMALL ANIMALS; PET SCANNER; RESOLUTION; MICROPET; RECEPTORS; DESIGN;
Keywords:
in vivo imaging of small animals; positron emission tomography; image data analysis; imaging instrumentation; rat model of disease; neuroimaging; stereotactic head holder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Rubins, DJ Univ Calif Los Angeles, Sch Med, Crump Inst Mol Imaging, Dept Mol & Med Pharmacol, 1833 Leconte Ave,CHS 28-115, Los Angeles, CA USA Univ Calif Los Angeles 1833 Leconte Ave,CHS 28-115 Los Angeles CA USA
Citazione:
D.J. Rubins et al., "Evaluation of a stereotactic frame for repositioning of the rat brain in serial positron emission tomography imaging studies", J NEUROSC M, 107(1-2), 2001, pp. 63-70

Abstract

For serial imaging studies of the rat brain with positron emission tomography (PET), reproducible positioning of the head can facilitate spatial alignment of images and quantitative analysis. To achieve this aim, we constructed a plastic head frame and tested the positioning reproducibility on a high-resolution small-animal PET scanner, microPET. Two sets of ear bars, with tapers of either 18 degrees (sharp) or 45 degrees (blunt), were evaluatedfor their relative precision in securing the animal to the frame. For sequential positioning of an animal, average distances from the mean position of 0.51 mm (SD 0.41 mm) and 0.91 mm (SD 0.48 mm) were measured with the sharp and blunt ear bars, respectively. These results show that a rat brain canbe reproducibly positioned using the frame, with a variation of position less than the spatial resolution of modern animal PET scanners. Brain regions of interest defined on one scan and copied across subsequent scans of a frame-repositioned animal resulted in an average coefficient of variation of5.4% (SD 2.7%) using the sharp ear bars and 6.8% (SD 2.5%) using the bluntear bars. This methodology has the potential to improve quantitative assessment for serial PET studies. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:49:21