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Titolo:
GABAergic inhibition antagonizes adaptive adjustment of the owl's auditoryspace map during the initial phase of plasticity
Autore:
Zheng, WM; Knudsen, EI;
Indirizzi:
Stanford Univ, Sch Med, Dept Neurobiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ept Neurobiol, Stanford, CA 94305 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 21, anno: 2001,
pagine: 4356 - 4365
SICI:
0270-6474(20010615)21:12<4356:GIAAAO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIENCE-DEPENDENT PLASTICITY; LONG-TERM POTENTIATION; INTERAURAL TIME DIFFERENCE; OCULAR DOMINANCE PLASTICITY; VISUAL-CORTEX; CRITICAL-PERIOD; BARN OWL; INFERIOR COLLICULUS; SYNAPTIC PLASTICITY; OPTIC TECTUM;
Keywords:
experience-dependent plasticity; sensitive period; inferior colliculus; bicuculline; APV-5; NMDA receptor; GABA(A) receptor; iontophoresis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Zheng, WM Stanford Univ, Sch Med, Dept Neurobiol, Sherman Fairchild Bldg, Stanford, CA 94305 USA Stanford Univ Sherman Fairchild Bldg Stanford CA USA94305 5 USA
Citazione:
W.M. Zheng e E.I. Knudsen, "GABAergic inhibition antagonizes adaptive adjustment of the owl's auditoryspace map during the initial phase of plasticity", J NEUROSC, 21(12), 2001, pp. 4356-4365

Abstract

We studied the influence of GABA-mediated inhibition on adaptive adjustment of the owl's auditory space map during the initial phase of plasticity. Plasticity of the auditory space map was induced by subjecting owls to a chronic prismatic displacement of the visual field. In the initial stages of plasticity, inhibition suppressed responses to behaviorally appropriate, newly functional excitatory inputs. As a result, adaptive changes in excitatory input were only partially expressed as postsynaptic spike activity. This masking effect of inhibition on map plasticity did not depend on the activity of NMDA receptors at the synapses that supported the newly learned responses. On the basis of these results, we propose that the pattern of feedforward inhibition is less dynamic than the pattern of feedforward excitation at the site of plasticity. As a result, initially in the adjustment processthe preexisting pattern of feedforward GABAergic inhibition opposes changes in the auditory space map and tends to preserve the established response properties of the network. The implications of this novel role of inhibition for the functional plasticity of the brain are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 15:03:37