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Titolo:
Unique functional properties of on and off pathways in the developing mammalian retina
Autore:
Wang, GY; Liets, LC; Chalupa, LM;
Indirizzi:
Univ Calif Davis, Sect Neurobiol Physiol & Behav, Div Biol Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 av, Div Biol Sci, Davis, CA 95616 USA Univ Calif Davis, Sch Med, Dept Ophthalmol, Davis, CA 95616 USA Univ CalifDavis Davis CA USA 95616 Dept Ophthalmol, Davis, CA 95616 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 21, anno: 2001,
pagine: 4310 - 4317
SICI:
0270-6474(20010615)21:12<4310:UFPOOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED AFFERENT ACTIVITY; ACTION-POTENTIAL ACTIVITY; GANGLION-CELL DENDRITES; CAT RETINA; POSTNATAL-DEVELOPMENT; FERRET RETINA; GLUTAMATE RECEPTORS; ROD PHOTORECEPTORS; BIPOLAR CELLS; ON-CENTER;
Keywords:
development; retinal ganglion cell; APB; dendritic stratification; On and Off pathways; retina; visual system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Chalupa, LM Univ Calif Davis, Sect Neurobiol Physiol & Behav, Div Biol Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Sci, Davis, CA 95616 USA
Citazione:
G.Y. Wang et al., "Unique functional properties of on and off pathways in the developing mammalian retina", J NEUROSC, 21(12), 2001, pp. 4310-4317

Abstract

In the mature retina, the dendrites of On and Off ganglion cells are segregated into separate sublaminas of the inner plexiform layer, but early in development these processes are multistratified, ramifying more widely within this synaptic layer. The dendritic pattern exhibited by immature ganglioncells suggests that there may be a functional convergence of On and Off pathways in the developing retina, but previous studies have provided evidence against this. Here we demonstrate by patch-clamp recordings and dye filling that ganglion cells with multistratified dendrites respond to the onset,as well as the offset, of light. We further show that, in the dark-adaptedretina, the glutamate analog 2-amino-4-phosphonobutric acid abolishes On and Off discharges in ganglion cells with multistratified dendrites. In contrast, in cells with stratified dendrites, this drug selectively blocks On responses. These findings provide evidence for unique functional attributes of On and Off pathways in the developing retina. The properties of immatureganglion cells documented here have important implications for the roles ascribed to neuronal activity in refining connections during the early development of the visual system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:04:14