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Titolo:
NMDA receptor-mediated Na+ signals in spines and dendrites
Autore:
Rose, CR; Konnerth, A;
Indirizzi:
Univ Munich, Inst Physiol, D-80802 Munich, Germany Univ Munich Munich Germany D-80802 Inst Physiol, D-80802 Munich, Germany
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 21, anno: 2001,
pagine: 4207 - 4214
SICI:
0270-6474(20010615)21:12<4207:NRNSIS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY POSTSYNAPTIC POTENTIALS; PROPAGATING ACTION-POTENTIALS; CEREBELLAR PURKINJE NEURONS; LONG-TERM POTENTIATION; CA1 PYRAMIDAL NEURONS; HIPPOCAMPAL-NEURONS; CALCIUM DYNAMICS; INTRACELLULAR SODIUM; FINE DENDRITES; SINGLE SPINES;
Keywords:
dendrite; spine; two-photon imaging; sodium; NMDA; coincidence detection; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Rose, CR Univ Munich, Inst Physiol, Biedersteiner Str 29, D-80802 Munich, Germany Univ Munich Biedersteiner Str 29 Munich Germany D-80802 Germany
Citazione:
C.R. Rose e A. Konnerth, "NMDA receptor-mediated Na+ signals in spines and dendrites", J NEUROSC, 21(12), 2001, pp. 4207-4214

Abstract

Spines and dendrites of central neurons represent an important site of synaptic signaling and integration. Here we identify a new, synaptically mediated spine signal with unique properties. Using two-photon Na+ imaging, we show that suprathreshold synaptic stimulation leads to transient increases in Na+ concentration in postsynaptic spines and their adjacent dendrites. This local signal is restricted to a dendritic domain near the site of synaptic input. In presumed active spines within this domain, the Na+ level increases by 30-40 mM even during short bursts of synaptic stimulation. During along-term potentiation induction protocol (100 Hz, 1 sec), the Na+ level in the active spines reaches peak amplitudes of similar to 100 mM. We find that the Na+ transients are mainly mediated by Na+ entry through NMDA receptor channels and are detected during the coincident occurrence of synaptic potentials and backpropagating action potentials. The large amplitudes of the Na+ transients and their location on dendritic spines suggest that this signal is an important determinant of electrical and biochemical spine characteristics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:45:24