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Titolo:
Drug dosage in patients with renal failure optimized by immediate concurrent feedback
Autore:
Falconnier, AD; Haefeli, WE; Schoenenberger, RA; Surber, C; Martin-Facklam, M;
Indirizzi:
Univ Heidelberg, Dept Internal Med 6, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany Univ Hosp, Div Clin Pharmacol, Basel, Switzerland Univ Hosp Basel Switzerland osp, Div Clin Pharmacol, Basel, Switzerland Univ Hosp, Div Gen Internal Med, Basel, Switzerland Univ Hosp Basel Switzerland p, Div Gen Internal Med, Basel, Switzerland Univ Hosp, Inst Hosp Pharm, Dept Internal Med, Basel, Switzerland Univ Hosp Basel Switzerland harm, Dept Internal Med, Basel, Switzerland
Titolo Testata:
JOURNAL OF GENERAL INTERNAL MEDICINE
fascicolo: 6, volume: 16, anno: 2001,
pagine: 369 - 375
SICI:
0884-8734(200106)16:6<369:DDIPWR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOSPITALIZED-PATIENTS; SERUM CREATININE; EVENTS; SYSTEM; ACCUMULATION; METABOLITES; COSTS;
Keywords:
kidney failure; drug therapy; drug costs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Martin-Facklam, M Univ Heidelberg, Dept Internal Med 6, Bergheimer Str 58,D-69115 Heidelberg, Germany Univ Heidelberg Bergheimer Str 58 Heidelberg Germany D-69115
Citazione:
A.D. Falconnier et al., "Drug dosage in patients with renal failure optimized by immediate concurrent feedback", J GEN INT M, 16(6), 2001, pp. 369-375

Abstract

Objective: To examine the impact of immediate concurrent feedback on dose adjustment in patients with renal failure. Design: prospective 12-month study in patients with various degrees of renal failure, with comparison to a retrospective control group. Setting: A 39-bed unit of a university hospital providing primary and tertiary care. Patients: Patients with renal failure (estimated creatinine clearance lessthan or equal to 50 mL/min) receiving at least 1 pharmacologically active drug. Interventions: Education of physicians and immediate concurrent feedback on the ward giving estimated creatinine clearance and dose recommendations for renally eliminated drugs adjusted to individual renal function. Measurements and Main Results: The percentage of dosage regimens adjusted to renal function and cost assessment of drug therapy were calculated. Overall, 17% of the patients had at least 1 estimated creatinine clearance lessthan or equal to 50 mL/min. In the intervention group, the dose of 81% of renally eliminated drugs was adjusted to renal function, compared with 33% in the control group (P <.001). The mean difference in cost between standard and adjusted dose of renally eliminated drugs in the intervention and control groups was 5.3 <plus/minus> 12.3 and 0.75 +/- 2.8 Swiss francs (approximately US$3.5 and US$0.5), respectively (P <.001), accounting for 16.5% and 2.8%, respectively, of daily medication costs of all drugs. Conclusions: The proportion of doses of renally eliminated drugs adjusted to renal function can be substantially increased by immediate concurrent feedback. This saves drug costs and has the potential to prevent adverse drugreactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:49:25