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Titolo:
Inhibition of chitin synthetase from Saccharomyces cerevisiae by a new UDP-GlcNAc analogue
Autore:
Behr, JB; Gautier-Lefebvre, I; Mvondo-Evina, C; Guillerm, G; Ryder, NS;
Indirizzi:
UFR Sci, UMR 6519, Chim Bioorgan Lab, F-51687 Reims, France UFR Sci Reims France F-51687 9, Chim Bioorgan Lab, F-51687 Reims, France Novartis Res Inst, A-1235 Vienna, Austria Novartis Res Inst Vienna Austria A-1235 Res Inst, A-1235 Vienna, Austria
Titolo Testata:
JOURNAL OF ENZYME INHIBITION
fascicolo: 2, volume: 16, anno: 2001,
pagine: 107 - 112
SICI:
8755-5093(2001)16:2<107:IOCSFS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-WALL BIOSYNTHESIS; NIKKOMYCIN ANALOGS; CANDIDA-ALBICANS; POLYOXIN; SYNTHASE; MECHANISMS; AZASUGARS; MODE;
Keywords:
chitin synthetase; inhibition; transition state analogue; glycosyltransferase; azasugar nucleotide; UDP-GlcNAc analogue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Guillerm, G UFR Sci, UMR 6519, Chim Bioorgan Lab, BP 1039, F-51687 Reims, France UFR Sci BP 1039 Reims France F-51687 9, F-51687 Reims, France
Citazione:
J.B. Behr et al., "Inhibition of chitin synthetase from Saccharomyces cerevisiae by a new UDP-GlcNAc analogue", J ENZ INHIB, 16(2), 2001, pp. 107-112

Abstract

The synthesis and biological evaluation of a new UDP-GlcNAc competitor (I), designed to mimic the transition state of the sugar donor in the enzymatic reaction catalysed by chitin synthetase, is described. Compound (I) was found to competitively inhibit chitin synthetase from Saccharomyces cerevisiae with respect to UDP-G1cNAc, but displayed minimal antifungal activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:03:27