Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Post-prandial decrease of circulating human ghrelin levels
Autore:
Tschop, M; Wawarta, R; Riepl, RL; Friedrich, S; Bidlingmaier, M; Landgraf, R; Folwaczny, C;
Indirizzi:
Univ Munich, Klinikum Innenstadt, Med Klin, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 dt, Med Klin, D-80336 Munich, Germany
Titolo Testata:
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
fascicolo: 6, volume: 24, anno: 2001,
pagine: RC19 - RC21
SICI:
0391-4097(200106)24:6<RC19:PDOCHG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECRETION; PITUITARY; STOMACH;
Keywords:
gastric emptying; ghrelin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Folwaczny, C Univ Munich, Klinikum Innenstadt, Med Klin, Ziemssenstr 1, D-80336 Munich,Germany Univ Munich Ziemssenstr 1 Munich Germany D-80336 ich,Germany
Citazione:
M. Tschop et al., "Post-prandial decrease of circulating human ghrelin levels", J ENDOC INV, 24(6), 2001, pp. RC19-RC21

Abstract

Ghrelin, an endogenous ligand of the GH secretagogue-receptor, has recently been shown to stimulate GH secretion and to have orexigenic and adipogenic effects in rodents, but little is known about its regulation and biological function in humans. Gastric motor function is under control of the central nervous system; however, the afferent and efferent loops of this feedback control mechanism remain to be elucidated. In the study presented here weinvestigated the effect of nutrient intake on circulating human ghrelin levels, and a possible association between ghrelin levels and gastric emptying. Ten healthy volunteers received a standard meal after an overnight fast. Food intake significantly decreased plasma ghrelin levels from 248.5 +/- 15.0 to 179.5 +/- 17.9 fmol/ml (120 min after meal, p = 0.047). Gastric emptying half-time (non-invasive C-13-octanoic acid breath test) was correlatedwith fasting plasma ghrelin levels (r = 0.74, p = 0.0013), Ghrelin appearsto be one possible candidate to provide feedback signaling between nutrient intake, gastric motor function and the central nervous system, (J, Endocrinol, Invest. 24: RC19-RC21, 2001) (C) 2001, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:24:33