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Titolo:
Intrinsic connectivity of the rat subiculum: I. Dendritic morphology and patterns of axonal arborization by pyramidal neurons
Autore:
Harris, E; Witter, MP; Weinstein, G; Stewart, M;
Indirizzi:
SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Brooklyn NY USA 11203 Pharmacol, Brooklyn, NY 11203 USA Vrije Univ Amsterdam, Fac Med, Dept Anat & Embryol, Grad Sch Neurosci Amsterdam,Inst Neurosci, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 BT erdam, Netherlands
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 4, volume: 435, anno: 2001,
pagine: 490 - 505
SICI:
0021-9967(20010709)435:4<490:ICOTRS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROPHYSIOLOGICALLY-DEFINED CLASSES; EPILEPTIFORM ACTIVITY; VENTRAL SUBICULUM; NITRIC-OXIDE; VITRO; HIPPOCAMPAL; ORGANIZATION; PROJECTIONS; SLICES; RESPONSES;
Keywords:
parahippocampal region; hippocampus; limbic cortex; excitatory synapse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Stewart, M SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, Box 31, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Box 31 Brooklyn NY USA 11203 yn, NY 11203 USA
Citazione:
E. Harris et al., "Intrinsic connectivity of the rat subiculum: I. Dendritic morphology and patterns of axonal arborization by pyramidal neurons", J COMP NEUR, 435(4), 2001, pp. 490-505

Abstract

The dendritic and axonal morphology of rat subicular neurons was studied in single cells labeled with Neurobiotin. Electrophysiological classification of cells as intrinsic burst firing or regular spiking neurons was correlated with morphologic patterns and cell locations. Every cell had dendritic branches that reached the outer molecular layer, with most cells having branches that reached the hippocampal fissure. All but two pyramidal cells hadaxon collaterals that entered the deep white matter (alveus). Branching patterns of apical dendrites varied as a function of the cell's soma locationalong the fissure-alveus axis of the cell layer. The first major dendriticbranch point for most cells occurred at the superficial edge of the cell layer giving deep cells long primary apical dendrites and superficial cells short or absent primary apical dendrites. In contrast, basal dendritic arbors were similar across cells regardless of cell position. Apical and basal dendrites of all cells had numerous spines. Superficial and deep cells alsodiffered in axonal collateralization. Deep cells (mostly intrinsically bursting [IB] class) had one or more ascending axon collaterals that typicallyremained within the region circumscribed by their apical dendrites. Superficial cells (mostly regular spiking [RS] class) tended to have axon collaterals that reached longer distances in the cell layer. Numerous varicositiesand axonal extensions were present on axon collaterals in the cell layer and in the apical dendritic region, suggesting intrinsic connectivity. Axonal varicosities and extensions were found on axons that entered presubiculum, entorhinal cortex or CA1, supporting the notion that these were projection cells. Local collaterals were distinctly thinner than collaterals that would leave the subiculum, suggesting little or no myelin on local collaterals and some myelin on efferent fibers. We conclude that both IB and RS classes of subicular principal cells make synaptic contacts in and apical to thecell layer. Based on the patterns of axonal arborization, we suggest that subiculum has at least a crude columnar and laminar architecture, with ascending collaterals of deep cells forming columns and broader axonal arbors of superficial cells serving to distribute activity across multiple columns. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:03:10