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Titolo:
Developmental regulation of CPG15 expression in Xenopus
Autore:
Nedivi, E; Javaherian, A; Cantallops, I; Cline, HT;
Indirizzi:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab Cold Spring Harbor NY USA 11724 rbor, NY 11724 USA SUNY Stony Brook, Grad Program Genet, Stony Brook, NY 11790 USA SUNY StonyBrook Stony Brook NY USA 11790 enet, Stony Brook, NY 11790 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 4, volume: 435, anno: 2001,
pagine: 464 - 473
SICI:
0021-9967(20010709)435:4<464:DROCEI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; IMMUNOGLOBULIN SUPERFAMILY; GABA IMMUNOREACTIVITY; NEURITE OUTGROWTH; NEURAL ACTIVITY; VISUAL-SYSTEM; GROWTH-FACTOR; OPTIC TECTUM; PROTEIN; GENE;
Keywords:
neuritin; ligand; retinotectal; GPI; spinal cord; amphibian; plasticity; visual system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cline, HT Cold Spring Harbor Lab, POB 100,1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA Cold Spring Harbor Lab POB 100,1 Bungtown Rd Cold Spring Harbor NY USA 11724
Citazione:
E. Nedivi et al., "Developmental regulation of CPG15 expression in Xenopus", J COMP NEUR, 435(4), 2001, pp. 464-473

Abstract

Mechanisms controlling dendritic arbor formation affect the establishment of neuronal circuits. Candidate plasticity gene 15 (CPG15) is a glycosylphosphatidyl inositol (GPI)-linked activity-induced protein that has been shown to function as an intercellular signaling molecule that can promote the morphological and physiological development of the Xenopus retinotectal system. A thorough understanding of CPG15 function requires knowledge of the spatiotemporal expression of the endogenous protein. We therefore cloned Xenopus cpg15 and used RNA in situ hybridization and immunohistochemistry to determine the pattern of CPG15 expression. cpg15 mRNA and CPG15 protein are first detectable in the developing spinal cord and become widespread as development proceeds. CPG15 is expressed in sensory regions of the brain, including the visual, auditory, and olfactory systems. Within the retina, CPG15 is only expressed in retinal ganglion cells. CPG15 protein is concentrated in axon tracts, including retinal axons. These data support a model in which CPG15 expressed in retinal ganglion cells is trafficked to retinal axone,where it modulates postsynaptic dendritic arbor elaboration, and synaptic maturation. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:01:04