Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Rac1 activity is required for the activation of hypoxia-inducible factor 1
Autore:
Hirota, K; Semenza, GL;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Pediat & Med, Inst Med Genet, Baltimore,MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 d Genet, Baltimore,MD 21287 USA Kyoto Univ, Kyoto Univ Hosp, Dept Anesthesia, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 sp, Dept Anesthesia, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 24, volume: 276, anno: 2001,
pagine: 21166 - 21172
SICI:
0021-9258(20010615)276:24<21166:RAIRFT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; TUMOR-SUPPRESSOR PROTEIN; FACTOR 1-ALPHA HIF-1-ALPHA; NF-KAPPA-B; TRANSCRIPTIONAL ACTIVITY; FACTOR-I; PHOSPHATIDYLINOSITOL 3-KINASE; SIGNALING PATHWAY; ALPHA-SUBUNIT; SMALL GTPASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Semenza, GL Johns Hopkins Univ, Sch Med, Dept Pediat & Med, Inst Med Genet, Baltimore,MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 timore,MD 21287 USA
Citazione:
K. Hirota e G.L. Semenza, "Rac1 activity is required for the activation of hypoxia-inducible factor 1", J BIOL CHEM, 276(24), 2001, pp. 21166-21172

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediatescellular and systemic homeostatic responses (including erythropoiesis, angiogenesis, and glycolysis) to reduced O-2 availability in mammals. Hypoxia induces both the protein expression and transcriptional activity of the HIF-1 alpha subunit. However, the molecular mechanisms of sensing and signal transduction by which changes in O-2 concentration result in changes in HIF-1 activity are poorly understood. We report here that the small GTPase Rad is activated in response to hypoxia and is required for the induction of HIF-1 alpha protein expression and transcriptional activity in hypoxic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:00:37