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Titolo:
One-year dog toxicity study of D-002 a mixture of aliphatic alcohols
Autore:
Aleman, C; Rodeiro, I; Noa, M; Menendez, R; Gamez, R; Hernandez, C; Mas, R;
Indirizzi:
Natl Ctr Sci Res, Ctr Nat Prod, Dept Toxicol, Havana, Cuba Natl Ctr Sci Res Havana Cuba , Ctr Nat Prod, Dept Toxicol, Havana, Cuba
Titolo Testata:
JOURNAL OF APPLIED TOXICOLOGY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 179 - 184
SICI:
0260-437X(200105/06)21:3<179:ODTSOD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXICOLOGY; BEESWAX; RATS;
Keywords:
D-002; aliphatic primary alcohols; anti-ulcer drugs; beagle dogs; chronic toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Aleman, C Natl Ctr Sci Res, Ctr Nat Prod, Dept Toxicol, Havana, Cuba Natl Ctr Sci Res Havana Cuba Prod, Dept Toxicol, Havana, Cuba
Citazione:
C. Aleman et al., "One-year dog toxicity study of D-002 a mixture of aliphatic alcohols", J APPL TOX, 21(3), 2001, pp. 179-184

Abstract

D-002 is a mixture of high-molecular-weight aliphatic alcohols, obtained from bees wax (Apis mellifera), with mild anti-inflammatory properties and effective anti-ulcer activities demonstrated in experimental models. This study investigated the oral toxicity of D-002 administered for 1 year to beagle dogs. Twenty-four beagle dogs (12 males and 12 females) were distributedrandomly in three experimental groups (four animals per group): a control and two treated groups received D-002 at 50 and 250 mg kg(-1) (7 days/week)by gastric gavage, Overall, D-002 was well tolerated throughout the study. No signs or symptoms of toxicity were observed, and no mortality occurred during the study, All groups showed similar weight gain and food consumption. No hematological, blood biochemical or histopathological disturbances attributable to treatment were observed. This study shows no drug-related toxicity induced by long-term administration of up to 250 mg kg(-1) D-002 to beagle dogs. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:47:08