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Titolo:
Incidence and determinants of bacterial infections in HIV-positive patients receiving anti-Pneumocystis carinii/Toxoplasma gondii primary prophylaxiswithin a randomized clinical trial
Autore:
Murri, R; Ammassari, A; Pezzotti, P; Cingolani, A; De Luca, A; Pallavicini, F; Grillo, R; Antinori, A;
Indirizzi:
Catholic Univ, Dept Infect Dis, I-00168 Rome, Italy Catholic Univ Rome Italy I-00168 v, Dept Infect Dis, I-00168 Rome, Italy Catholic Univ, Inst Microbiol, I-00168 Rome, Italy Catholic Univ Rome Italy I-00168 iv, Inst Microbiol, I-00168 Rome, Italy Inst Super Sanita, Ctr Operat AIDS, Rome, Italy Inst Super Sanita Rome Italy Super Sanita, Ctr Operat AIDS, Rome, Italy Natl Inst Infect Dis L Spallanzani, Rome, Italy Natl Inst Infect Dis L Spallanzani Rome Italy Spallanzani, Rome, Italy
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 1, volume: 27, anno: 2001,
pagine: 49 - 55
SICI:
1525-4135(20010501)27:1<49:IADOBI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; COMMUNITY-ACQUIRED PNEUMONIA; TRIMETHOPRIM-SULFAMETHOXAZOLE; CARINII PNEUMONIA; RISK-FACTORS; COTE-DIVOIRE; NEUTROPENIA; BACTEREMIA; AIDS; MORBIDITY;
Keywords:
cotrimoxazole; bacterial infections; primary prophylaxis; Pneumocystis carinii;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Murri, R Catholic Univ, Dept Infect Dis, Lgo A Gemelli 8, I-00168 Rome, Italy Catholic Univ Lgo A Gemelli 8 Rome Italy I-00168 168 Rome, Italy
Citazione:
R. Murri et al., "Incidence and determinants of bacterial infections in HIV-positive patients receiving anti-Pneumocystis carinii/Toxoplasma gondii primary prophylaxiswithin a randomized clinical trial", J ACQ IMM D, 27(1), 2001, pp. 49-55

Abstract

We assessed the incidence and determinants of bacteremia, pneumonia, and sinusitis/otitis in HIV-positive people receiving cotrimoxazole (CTX) or dapsone-pyrimethamine (DP) for primary prophylaxis of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) within a randomized clinicaltrial. In total, 244 patients were randomized: 122 were assigned to CTX and 122 to DP. In the cohort, 22 bacteremia, 63 pneumonia, and 39 sinusitis/otitis cases were observed. Incidence rates of bacteremia, pneumonia, and sinusitis/otitis as well as the 2-year probability of remaining free from anybacterial infection were not significantly different between the two groups. At multivariate analysis, the risks of developing bacteremia and pneumonia were found to be independently increased by the use of a central venous catheter (hazard ratio [HR], 4.48; p < .05 and HR, 4.13; p < .01, respectively) and by hospitalization (HR, 28.82; p < .05 and HR, 10.15; p < .05, respectively). In conclusion, CTX at the dosage employed for primary PCP/TE prophylaxis does not seem to protect against bacterial infections more than second-line DP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:01:42