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Titolo:
Lipodystrophy in HIV-infected children is associated with high viral load and low CD4(+)-lymphocyte count and CD4(+)-lymphocyte percentage at baseline and use of protease inhibitors and stavudine
Autore:
Arpadi, SM; Cuff, PA; Horlick, M; Wang, J; Kotler, DP;
Indirizzi:
Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Comprehens HIV Care Ctr, New York, NY 10025 USA Columbia Univ Coll Phys & Surg New YorkNY USA 10025 w York, NY 10025 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 1, volume: 27, anno: 2001,
pagine: 30 - 34
SICI:
1525-4135(20010501)27:1<30:LIHCIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; CARDIOVASCULAR-DISEASE; AMERICAN CHILDREN; MEN; LIPOPROTEINS; OBESITY; THERAPY; FOLLOW; DEATH; RISK;
Keywords:
regional fat changes; lipodystrophy; HIV-infected children; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Arpadi, SM Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Comprehens HIV Care Ctr, 1111 Amsterdam Ave, New York, NY 10025 USA Columbia Univ Coll Phys & Surg 1111 Amsterdam Ave New York NY USA 10025
Citazione:
S.M. Arpadi et al., "Lipodystrophy in HIV-infected children is associated with high viral load and low CD4(+)-lymphocyte count and CD4(+)-lymphocyte percentage at baseline and use of protease inhibitors and stavudine", J ACQ IMM D, 27(1), 2001, pp. 30-34

Abstract

Alterations in regional fat, often associated with abnormalities in lipid and insulin metabolism, have been reported in HIV-infected adults. To determine whether similar abnormalities occur in children with HIV, patterns of change in regional body fat distribution were determined by dual energy x-ray absorptiometry in 28 prepubertal HIV-infected children. Eight (29%) children experienced lipodystrophy (LD), defined as extremity lipoatrophy together with trunk fat accumulation. Despite a mean body weight increase of 2.9+/- 2.4 kg, children with LD experienced a mean loss of total fat in contrast to children without LD who increased total fat (-0.151 +/- 0.324 versus0.981 +/- 1.041 kg; p < .01). Children with LD had significantly higher levels of HIV RNA and lower CD4 count and percentage at baseline. LD was associated with use of protease inhibitors or stavudine, (odds ratio [OR], 7.0,95% confidence interval [CI], 1.1-45.2, p = .04; OR, 9.0, 95% CI, 1.4-59.8, p = .03, respectively). This observational study suggests that during a time in childhood when accumulation of extremity and trunk fat is expected, some HIV-infected children experience changes in fat distribution that are similar to HIV-associated LD reported in adults. Studies to determine whether HIV-infected children with changes in regional fat also experience increases in "atherogenic" lipids and insulin resistance as described in adults with HIV-associated LD are warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 17:20:31