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Titolo:
Increase and plateau of CD4 T-cell counts in the 3 1/2 years after initiation of potent antiretroviral therapy
Autore:
Tarwater, PM; Margolick, JB; Jin, JH; Phair, JP; Detels, R; Rinaldo, C; Giorgi, J; Munoz, A;
Indirizzi:
John Hopkins Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA John Hopkins Sch Hyg & Publ Hlth Baltimore MD USA 21205 ore, MD 21205 USA Northwestern Univ, Sch Med, Chicago, IL USA Northwestern Univ Chicago IL USA hwestern Univ, Sch Med, Chicago, IL USA Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA Publ Hlth, Los Angeles, CA USA Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Grad Sch Publ Hlth, Pittsburgh, PA USA Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA , Sch Med, Los Angeles, CA USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 27, anno: 2001,
pagine: 168 - 175
SICI:
1525-4135(20010601)27:2<168:IAPOCT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICENTER AIDS COHORT; HIV-INFECTION; VIRAL-LOAD; RECONSTITUTION; SUBSETS; DISEASE; HAART;
Keywords:
potent ART; CD4 cells; longitudinal studies; epidemiologic methods;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tarwater, PM John Hopkins Sch Hyg & Publ Hlth, Dept Epidemiol, 615 N WolfeSt,Rm E-7137, Baltimore, MD 21205 USA John Hopkins Sch Hyg & Publ Hlth 615N Wolfe St,Rm E-7137 Baltimore MD USA 21205
Citazione:
P.M. Tarwater et al., "Increase and plateau of CD4 T-cell counts in the 3 1/2 years after initiation of potent antiretroviral therapy", J ACQ IMM D, 27(2), 2001, pp. 168-175

Abstract

We evaluated CD4 cell counts over a 3 1/2 year period following the initiation of potent antiretroviral therapy (ART) in the Multicenter AIDS Cohort Study. The study population included 314 HIV-infected gay men who provided CD4 cell counts for at least 2 years after the initiation of potent ART. Trends in CD4 cell counts and plasma HIV-RNA were analyzed by regression methods that incorporated the statistical dependencies of outcomes measured over time within individuals. Regard less of CD4 cell count at initiation of potent ART, CD4 cell counts increased significantly (p < .05) in the first 2years after initiation. However, between 2 and 3 1/2 years after initiation, these counts neither increased nor decreased, The pattern of the proportion with plasma HIV-RNA < 400 copies/ml was similar to CD4 cell count (i.e., increased significantly after initiation and plateau in the subsequent 1 1/2 years). The single most important predictor of the steady state CD4 cell count that was maintained between 2 and 3 1/2 years after initiation was the change in plasma HIV-RNA in the first year after initiation of potent ART.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:12:42