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Titolo:
Hospitalization rates in an urban cohort after the introduction of highly active antiretroviral therapy
Autore:
Gebo, KA; Diener-West, M; Moore, RD;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Biostat, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Biostat, Baltimore, MD 21205USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 27, anno: 2001,
pagine: 143 - 152
SICI:
1525-4135(20010601)27:2<143:HRIAUC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTH-SERVICE USE; HIV-INFECTION; DRUG-USERS; IMPACT; PEOPLE; MORTALITY; ADMISSION; DISEASE; RISK;
Keywords:
hospitalization; highly active antiretroviral therapy; female gender; injection drug use;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, RD Johns Hopkins Univ, Sch Med, Dept Med, 1830 E Monument St,Rm 8059, Baltimore, MD 21205 USA Johns Hopkins Univ 1830 E Monument St,Rm 8059 Baltimore MD USA 21205
Citazione:
K.A. Gebo et al., "Hospitalization rates in an urban cohort after the introduction of highly active antiretroviral therapy", J ACQ IMM D, 27(2), 2001, pp. 143-152

Abstract

Objective: Previous studies have shown a decrease in hospitalization ratesassociated with the introduction of highly active antiretroviral therapy (HAART). To evaluate hospitalization rates and patterns in discharge diagnoses that changed between 1995 and 1998 and to examine risk factors for hospitalization in HIV-positive patients, we conducted a cohort study. Patients and Methods: All inpatient hospitalizations of 2,151 HIV-positivepatients enrolled in our university-based HIV clinic between January 1, 1994 and December 31, 1998 with a CD4 count within a 6-month calendar semester were examined to evaluate hospitalization rates, discharge diagnoses, andintensive care department use. Negative binomial regression was used to assess the effect of various risk factors on hospitalization. Results: Hospitalization rates decreased between 1995 and 1996 but increased between 1997 and 1998. In multivariate regression, female gender (incidence rate ratio [IRR], 1.45; p < .001), injection drug use (IRR, 1.36; p < .001), and having received no antiretroviral therapy were strong predictors of total hospitalization. White race, low CD4 count, and no antiretroviral treatment were strong predictors of hospitalization for an opportunistic infection. Female gender (IRR, 1.45; p < .001), African-American ethnicity (IRR, 1.22, p = .05), no antiretroviral treatment, and low CD4 counts were predictive of higher hospitalization rates for nonopportunistic infection-related diagnoses. Intensive care department-use was associated with white ethnicity (IRR, 1.86; p = .028), heterosexual transmission of HIV (IRR, 1.90; p = .009), no antiretroviral treatment, and low CD4 count at enrollment. Conclusions: Our data indicate that hospitalization rates decreased between 1995 and 1997 after introduction of HAART, but that they then increased between 1997 and 1998, particularly for diagnosed nonopportunistic infections. If these trends continue, it indicates that patients may be developing previously unseen comorbidities and that HAART may have reached or exceeded a threshold in its effectiveness in reducing the clinical morbidity that results in hospital admission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:52:55