Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Zidovudine genotypic resistance in HIV-1-infected newborns in the French Perinatal Cohort
Autore:
Masquelier, B; Chaix, ML; Burgard, M; Lechenadec, J; Doussin, A; Simon, F; Cottalorda, J; Izopet, J; Tamalet, C; Douard, D; Fleury, H; Mayaux, MJ; Blanche, S; Rouzioux, C;
Indirizzi:
Ctr Hosp Univ Necker Paris, Virol Lab, Paris, France Ctr Hosp Univ Necker Paris Paris France Paris, Virol Lab, Paris, France Ctr Hosp Univ Kremlin Bicetre, INSERM U292, Virol Lab, Le Kremlin Bicetre,France Ctr Hosp Univ Kremlin Bicetre Le Kremlin Bicetre France Bicetre,France Ctr Hosp Univ Bichat Paris, Virol Lab, Paris, France Ctr Hosp Univ Bichat Paris Paris France Paris, Virol Lab, Paris, France Ctr Hosp Univ Nice, Virol Lab, Nice, France Ctr Hosp Univ Nice Nice France Hosp Univ Nice, Virol Lab, Nice, France Ctr Hosp Univ Toulouse, Virol Lab, Toulouse, France Ctr Hosp Univ Toulouse Toulouse France use, Virol Lab, Toulouse, France Ctr Hosp Univ Marseille, Virol Lab, Marseille, France Ctr Hosp Univ Marseille Marseille France , Virol Lab, Marseille, France Hop Pellegrin, Serv Pediat, Bordeaux, France Hop Pellegrin Bordeaux France Pellegrin, Serv Pediat, Bordeaux, France Hop Necker, Serv Pediat, Paris, France Hop Necker Paris FranceHop Necker, Serv Pediat, Paris, France Ctr Hosp Univ Bordeaux, Hop Pellegrin, Virol Lab, F-33076 Bordeaux, FranceCtr Hosp Univ Bordeaux Bordeaux France F-33076 F-33076 Bordeaux, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 27, anno: 2001,
pagine: 99 - 104
SICI:
1525-4135(20010601)27:2<99:ZGRIHN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TO-CHILD TRANSMISSION; MATERNAL-INFANT TRANSMISSION; RANDOMIZED CONTROLLED TRIAL; HIGH-LEVEL RESISTANCE; DRUG-RESISTANCE; VERTICAL TRANSMISSION; ORAL ZIDOVUDINE; COTE-DIVOIRE; HIV-1;
Keywords:
HIV-1 mother-child transmission; zidovudine; drug resistance; AJ276519; AJ276552; variability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Masquelier, B Ctr Hosp Univ Bordeaux, Hop Pellegrin, Virol Lab, Pl Amelie Raba Leon, F-33076 Bordeaux, France Ctr Hosp Univ Bordeaux Pl Amelie Raba Leon Bordeaux France F-33076
Citazione:
B. Masquelier et al., "Zidovudine genotypic resistance in HIV-1-infected newborns in the French Perinatal Cohort", J ACQ IMM D, 27(2), 2001, pp. 99-104

Abstract

A retrospective study was set up to investigate the frequency of zidovudine (ZDV)-resistant HIV-1 in infected newborns after ZDV prophylaxis in the French Perinatal Cohort study. Nucleotide sequence analysis was carried out from 34 infants' isolates and18 maternal plasma samples. Mutations related to ZDV resistance were foundin the HIV-1 reverse transcriptase in 7 of 34 children (20%). Evidence of mother-child transmission of ZDV-resistant HIV-1 was found in 4 cases. Phylogenetic analysis showed that 14 of 34 HIV-1 isolates from the infants belonged to non-B subtypes. The presence of ZDV resistance-encoding mutations in the newborn isolates was associated with a longer total duration of exposure to ZDV. In a context of a wide HIV-1 variability, ZDV resistance can beone of the factors contributing to mother-child transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:47:32