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Titolo:
Regulation of virulence determinants in Staphylococcus aureus
Autore:
Arvidson, S; Tegmark, K;
Indirizzi:
Karolinska Inst, Microbiol & Tumorbiol Ctr, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Ctr, S-17177 Stockholm, Sweden
Titolo Testata:
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
fascicolo: 2, volume: 291, anno: 2001,
pagine: 159 - 170
SICI:
1438-4221(200105)291:2<159:ROVDIS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-LYSIN GENE; PROTEIN-A; GLOBAL REGULATOR; ALPHA-TOXIN; SAR LOCUS; NUCLEOTIDE-SEQUENCE; CHROMOSOMAL LOCUS; SEPTIC ARTHRITIS; RNA MOLECULE; AGR;
Keywords:
Staphylococcus aureus; agr; RNAIII; sar; virulence regulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Arvidson, S Karolinska Inst, Microbiol & Tumorbiol Ctr, S-17177 Stockholm,Sweden Karolinska Inst Stockholm Sweden S-17177 7 Stockholm, Sweden
Citazione:
S. Arvidson e K. Tegmark, "Regulation of virulence determinants in Staphylococcus aureus", INT J MED M, 291(2), 2001, pp. 159-170

Abstract

The pathogenicity of Staphylococcus aureus depends on the combined action of more than 40 different extracellular toxins, enzymes and cell surface proteins. A global regulator ngr controls the production of many of these virulence factors by a regulating RNA molecule, RNAIII. Most of the virulence genes regulated by RNAIII are also regulated by SarA and a family of homologous proteins. The Sar proteins appear to repress transcription of individual virulence genes or sets oi genes. As some Sar proteins also repress one or more sar homologous genes an increased production of a single Sar protein can result in decreased expression of some virulence genes, and an increased expression of others. Results are presented suggesting that RNAIII might function as an antirepressor, binding one or more of the Sar proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:25:51