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Titolo:
Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome C-dependent pathway in esophageal cancer cells
Autore:
Li, M; Wu, XY; Xu, XC;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Clin Canc Prevent 236, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 n Canc Prevent 236, Houston, TX 77030 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 2, volume: 93, anno: 2001,
pagine: 218 - 223
SICI:
0020-7136(20010715)93:2<218:IOABCI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CYCLOOXYGENASE-2 INHIBITOR; COLORECTAL-CANCER; EXPRESSION; MITOCHONDRIA; CARCINOMA; ASPIRIN; PREVENTION; RELEASE; GROWTH;
Keywords:
apoptosis; cytochrome c; cyclo-oxygenase; non-steroidal anti-inflammatory drugs; esophageal cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, XC Univ Texas, MD Anderson Canc Ctr, Dept Clin Canc Prevent 236, 1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd Houston TX USA 77030 on, TX 77030 USA
Citazione:
M. Li et al., "Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome C-dependent pathway in esophageal cancer cells", INT J CANC, 93(2), 2001, pp. 218-223

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) can induce tumor cells to undergo apoptosis in vitro. They have also shown cancer-preventive activity in vivo, The mechanism of their effects is, however, not well defined, We investigated the mechanism by which a new NSAID, NS398, induces apoptosis inesophageal cancer cell lines. NS398 decreased cell viability in 2 cyclo-oxygenase-2-positive (COX-2(+)) esophageal cancer cell lines but not in a COX-2(-) cell line. DNA fragmentation and TUNEL assays demonstrated that NS398induced the 2 COX-2(+) cancer cell lines to undergo apoptosis, The percentage of apoptosis induced by NS398 was associated with the level of COX-2 expression. Further investigation showed that the cytochrome c pathway was responsible for NS398-induced apoptosis; i.e., cytochrome c was released frommitochondria, caspase-9 and caspase-3 were activated and finally poly(ADP ribose)polymerase (PARP) was cleaved. Furthermore, the effect of NS398 was inhibited by the caspase inhibitor Z-DEVD-FMK and prostaglandin E-2, In contrast, bcl-2, bax, c-myc, Fas and Fas-ligand showed minor changes. altogether, our data suggest that induction of apoptosis by NS398 is associated with COX-2 expression and occurs through the cytochrome c-dependent pathway, which sequentially activates caspase-9 and caspase-3 and cleaves PARP, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:59:48