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Titolo:
CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by DAXX
Autore:
Hofmann, TG; Moller, A; Hehner, SP; Welsch, D; Droge, W; Schmitz, ML;
Indirizzi:
German Canc Res Ctr, Div Immunohistochem G0200, D-69120 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-69120 69120 Heidelberg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 2, volume: 93, anno: 2001,
pagine: 185 - 191
SICI:
0020-7136(20010715)93:2<185:CJASAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE PATHWAY; FAS LIGAND EXPRESSION; C-JUN; INDUCED APOPTOSIS; CELL-DEATH; REGULATING KINASE-1; CD95 APO-1/FAS; CARCINOMA CELLS; TNF RECEPTOR; KAPPA-B;
Keywords:
apoptosis; ASK1; CD95 receptor; DISC; JNK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitz, ML German Canc Res Ctr, Div Immunohistochem G0200, Neuenheimer Feld 280, D-69120 Heidelberg, Germany German Canc Res Ctr Neuenheimer Feld 280 Heidelberg Germany D-69120
Citazione:
T.G. Hofmann et al., "CD95-induced JNK activation signals are transmitted by the death-inducing signaling complex (DISC), but not by DAXX", INT J CANC, 93(2), 2001, pp. 185-191

Abstract

Here we investigated CD95-mediated JNK activation pathways and their physiological relevance by employing a variety of cell lines with deficiencies in individual signal transmitting proteins. JNK activation was completely dependent on the activation of caspases in type I and type II cells, as revealed by the inhibitory effects of the caspase inhibitors zVAD-fmk or the cowpoxvirus-encoded CrmA protein. Jurkat cells deficient in caspase-8 or expressing a dominant negative (DN) form of FADD were unable to induce JNK in response to CD95 ligation, indicating that these death-inducing signaling complex (DISC) proteins are required for signal transmission, Activation of caspases, JNK and apoptosis occurred with a markedly slower kinetics in cellsexpressing a DN version of ASK1, revealing an important contribution of ASK1 for these processes, A C-terminally truncated version of Daxx impaired CD95-mediated apoptosis without affecting the INK signal. DN forms of FADD, MKK4 and MKK7 completely inhibited CD95-mediated INK activation but remained without impact on cell killing, indicating that JNK activation is not required for the execution process of CD95-mediated cell killing. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:28:26