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Titolo:
A comparison of Fc epsilon RI-mediated RANTES release from human plateletsbetween allergic patients and healthy individuals
Autore:
Hasegawa, S; Tashiro, N; Matsubara, T; Furukawa, S; Ra, C;
Indirizzi:
Juntendo Univ, Sch Med, Allergy Res Ctr, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 s Ctr, Bunkyo Ku, Tokyo 1138421, Japan Yamaguchi Univ, Sch Med, Dept Pediat, Yamaguchi, Japan Yamaguchi Univ Yamaguchi Japan , Sch Med, Dept Pediat, Yamaguchi, Japan Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 v, Sch Med, Dept Immunol, Tokyo 113, Japan
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
, volume: 125, anno: 2001, supplemento:, 1
pagine: 42 - 47
SICI:
1018-2438(2001)125:<42:ACOFER>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-AFFINITY RECEPTOR; EPIDERMAL LANGERHANS CELLS; TRANSFECTED CELLS; IMMUNOGLOBULIN-E; GAMMA RECEPTOR; IGE RECEPTOR; EXPRESSION; ACTIVATION; ANTIBODIES; CHAIN;
Keywords:
platelets; IgE; Fc epsilon RI; RANTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ra, C Juntendo Univ, Sch Med, Allergy Res Ctr, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 1138421 Tokyo 1138421, Japan
Citazione:
S. Hasegawa et al., "A comparison of Fc epsilon RI-mediated RANTES release from human plateletsbetween allergic patients and healthy individuals", INT A AL IM, 125, 2001, pp. 42-47

Abstract

Background: Recently some studies have suggested that human platelets may play an important role in allergic inflammation through the high affinity IgE receptor (Fc epsilon RI), the low affinity IgE receptor (Fc epsilon RII/CD23) and the low affinity IgG receptor (Fc gamma RIIA/CD32) expressed on the cell surface. We reported that human platelets via the Fc epsilon RI induced the release of the chemical mediator serotonin and the chemokine RANTES (regulated upon activation, normal T expressed and presumably secreted), but the biological implication of human platelets in type I allergy has notyet been understood clearly. Methods: We compared the levels of RANTES release from platelets obtained from allergic patients and healthy individuals, stimulated with monoclonal antibody (Ab) to human Fc epsilon RI alpha -chain, or human myeloma IgE and anti-human IgE Ab. Results: We confirmed thatthe level of RANTES release from platelets of allergic patients stimulatedwith human IgE and anti-human IgE was significantly higher than that of healthy individuals. Conclusions: We demonstrated that the surface expressionlevels of Fc epsilon RI on the platelets from allergic patients and healthy individuals were not significantly different, but that the platelets of allergic patients were more activated by the IgE-Fc epsilon RI pathway than those of healthy individuals. Taken together, these results suggest a noveland important role for human platelets in perpetuating allergic inflammation through the IgE and Fc epsilon RI. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:29:38