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Titolo:
Effect of emedastine difumarate on CC chemokine-elicited eosinophil migration
Autore:
Saito, H; Yamamoto, N; Tomita, S; Taniguchi, M; Hasegawa, M; Akiyama, K; Kawaguchi, H; Takahashi, K;
Indirizzi:
Natl Sagamihara Hosp, Clin Res Ctr Rheumatol & Allergy, Kanagawa 2288522, Japan Natl Sagamihara Hosp Kanagawa Japan 2288522 rgy, Kanagawa 2288522, Japan Natl Sagamihara Hosp, Dept Dermatol, Kanagawa, Japan Natl Sagamihara HospKanagawa Japan osp, Dept Dermatol, Kanagawa, Japan Yokohama Municipal Med Coll, Dept Dermatol, Yokohama, Kanagawa, Japan Yokohama Municipal Med Coll Yokohama Kanagawa Japan ama, Kanagawa, Japan
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
, volume: 125, anno: 2001, supplemento:, 1
pagine: 22 - 28
SICI:
1018-2438(2001)125:<22:EOEDOC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EOTAXIN; CELLS; INTERLEUKIN-8; EXPRESSION; CYTOKINES; RANTES;
Keywords:
eosinophil migration; CC chemokine; emedastine difumarate; tyrosine kinase activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Saito, H Natl Sagamihara Hosp, Clin Res Ctr Rheumatol & Allergy, 18-1 Sakuradai, Kanagawa 2288522, Japan Natl Sagamihara Hosp 18-1 Sakuradai Kanagawa Japan 2288522 Japan
Citazione:
H. Saito et al., "Effect of emedastine difumarate on CC chemokine-elicited eosinophil migration", INT A AL IM, 125, 2001, pp. 22-28

Abstract

Emedastine difumarate (emedastine) is an antiallergic drug found among thederivatives which has a series of benzimidazole frames. It has been reported that emedastine can significantly inhibit the migration of eosinophils elicited by classical chemoattractants, including LTB4 or PAF. However, the effect of emedastine on the selective migration of eosinophils that have been stimulated with CC chemokines has not been examined. Emedastine at concentrations of 10 nM or higher strongly inhibited the eosinophil migration elicited by CC chemokines, including eotaxin, RANTES and MCP-3. Preincubationof the eosinophils with emedastine did not alter the expression of the CCR3 receptor, although a decrease in the concentration of intracellular calcium ions was observed after stimulation with 100 ng/ml of eotaxin. Herbimycin A, genistein, staurosporin and emedastine were all able to inhibit the eotaxin-elicited migration. Tyrosine kinase activity in the cytosol supernatant of eosinophils obtained after stimulation with eotaxin significantly decreased when the eosinophils were preincubated with emedastine. In addition,protein kinase A and protein kinase C activities in eotaxin-stimulated EoL-1 cell supernatants decreased significantly with emedastine pretreatment. These findings suggest that emedastine inhibits CC chemokine-elicited eosinophil mig ration by decreasing the activities of tyrosine kinase or proteinkinases but does not: alter CCR3 expression. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:31:35