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Titolo:
Immune response induction and new effector mechanisms possibly involved inprotection conferred by the Cuban anti-meningococcal BC vaccine
Autore:
Perez, O; Lastre, M; Lapinet, J; Bracho, G; Diaz, M; Zayas, C; Taboada, C; Sierra, G;
Indirizzi:
Finlay Inst, Dept Basic & Clin Immunol, Havana, Cuba Finlay Inst Havana Cuba y Inst, Dept Basic & Clin Immunol, Havana, Cuba
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 7, volume: 69, anno: 2001,
pagine: 4502 - 4508
SICI:
0019-9567(200107)69:7<4502:IRIANE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE VESICLE VACCINE; PERTUSSIS RESPIRATORY-INFECTION; CELL-MEDIATED-IMMUNITY; BORDETELLA-PERTUSSIS; IMMUNIZATION; MODULATION; CHILDREN; GAMMA; IL-13; TH1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Perez, O Finlay Inst, Dept Basic & Clin Immunol, POB 16017, Havana, Cuba Finlay Inst POB 16017 Havana Cuba unol, POB 16017, Havana, Cuba
Citazione:
O. Perez et al., "Immune response induction and new effector mechanisms possibly involved inprotection conferred by the Cuban anti-meningococcal BC vaccine", INFEC IMMUN, 69(7), 2001, pp. 4502-4508

Abstract

This report explores the participation of some afferent mechanisms in the immune response induced by the Cuban anti-meningococcal vaccine VA-MENGOC-BC, The induction of delayed-type hypersensitivity in nursing babies and lymphocyte proliferation after immunization is demonstrated. The presence of gamma interferon IFN-gamma and interleukin-2 (IL-2) mRNAs but absence of IL-4, IL-5, and IL-10 mRNAs were observed in peripheral blood mononuclear cells from immunized subjects after in vitro challenge with outer membrane vesicles. In addition, some effector functions were also explored. The presenceof opsonic activity was demonstrated in sera from vaccinees, The role of neutrophils as essential effector cells was shown. In conclusion, we have shown that, at least in the Cuban adult population, VA-MENGOC-BC induces mechanisms with a T-helper 1 pattern in the afferent and effector branches of the immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:21:07