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Titolo:
Interleukin-6 enhances production of Anti-OspC immunoglobulin G2b borreliacidal antibody
Autore:
Remington, MC; Munson, EL; Callister, SM; Molitor, ML; Christopherson, JA; DeCoster, DJ; Lovrich, SD; Schell, RF;
Indirizzi:
Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 State Lab Hyg, Madison, WI 53706 USA Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 biol & Immunol, Madison, WI 53706 USA Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Bacteriol, Madison, WI 53706 USA Gundersen Lutheran Med Ctr, Microbiol Res Lab, La Crosse, WI 54601 USA Gundersen Lutheran Med Ctr La Crosse WI USA 54601 La Crosse, WI 54601 USA Gundersen Lutheran Med Ctr, Infect Dis Sect, La Crosse, WI 54601 USA Gundersen Lutheran Med Ctr La Crosse WI USA 54601 La Crosse, WI 54601 USA
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 7, volume: 69, anno: 2001,
pagine: 4268 - 4275
SICI:
0019-9567(200107)69:7<4268:IEPOAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER-SURFACE-PROTEIN; LYME-DISEASE; ACTIVE IMMUNIZATION; BURGDORFERI INFECTION; IMMUNE-RESPONSE; MICE; VACCINE; SERODIAGNOSIS; EXPRESSION; CHALLENGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Schell, RF Univ Wisconsin, Wisconsin State Lab Hyg, 465 Henry Mall, Madison, WI 53706USA Univ Wisconsin 465 Henry Mall Madison WI USA 53706 WI 53706USA
Citazione:
M.C. Remington et al., "Interleukin-6 enhances production of Anti-OspC immunoglobulin G2b borreliacidal antibody", INFEC IMMUN, 69(7), 2001, pp. 4268-4275

Abstract

Protection against infection with Borrelia burgdorferi is dependent primarily on induction of complement-dependent antibody that can kill the spirochete. Measuring the production of sustained high levels of borreliacidal antibody is thus paramount for determining potential vaccine efficacy. We investigated the borreliacidal antibody response in sera and the amount of antibody produced by cultured lymph node cells of C3H/HeJ mice vaccinated with outer surface protein C (OspC), We showed that recombinant OspC was a weak stimulant of borreliacidal antibody production compared to whole cells of OspC-expressing B, burgdorferi. Mice vaccinated with B, burgdorferi in adjuvant produced a high level (titer, 5,120) of anti-OspC borreliacidal antibody, which waned rapidly. Similarly, borreliacidal antibody production by cultured lymph node cells from vaccinated mice peaked soon after vaccination and then decreased. Treatment of lymph node cells with interleukin-6 (IL-6) augmented borreliacidal antibody production, particularly immunoglobulin G2b, whereas treatment with anti-IL-6 inhibited the borreliacidal response. These findings demonstrate a previously unrecognized role for IL-6 in borreliacidal antibody production that may have important implications for vaccine development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:17:06