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Titolo:
The absorption, distribution and excretion of 1-and 2-[C-14]palmitoyl triacyglycerols in the rat
Autore:
Sanders, DJ; Howes, D; Earl, LK;
Indirizzi:
Unilever Res, SEAC Toxicol, Sharnbrook MK44 1LQ, Beds, England Unilever Res Sharnbrook Beds England MK44 1LQ ook MK44 1LQ, Beds, England
Titolo Testata:
FOOD AND CHEMICAL TOXICOLOGY
fascicolo: 7, volume: 39, anno: 2001,
pagine: 709 - 716
SICI:
0278-6915(200107)39:7<709:TADAEO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-MILK; FORMULA; INFANTS;
Keywords:
betapol; 1-palmitoyl triacylglycerols; 2-palmitoyl triacylglycerols; neonatal rats; whole body autoradiography; tissue distribution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Earl, LK Unilever Res, SEAC Toxicol, Colworth House, Sharnbrook MK44 1LQ, Beds, England Unilever Res Colworth House Sharnbrook Beds England MK44 1LQ land
Citazione:
D.J. Sanders et al., "The absorption, distribution and excretion of 1-and 2-[C-14]palmitoyl triacyglycerols in the rat", FOOD CHEM T, 39(7), 2001, pp. 709-716

Abstract

Human breast milk is rich in 2-palmitoyl 1,3 unsaturated triacyglycerols and during the neonatal period, when milk is the sole source of nutrients, their role could be particularly important. Betapol is a novel triacylglycerol mix resembling human breast milk in its high palmitic acid content and positional distribution. The total fat absorption from Betapol has been shown to be higher than fat from conventional infant milk formulas and closer to human breast milk in infants. However, the relative fate of purified palmitic acid esterified to glycerol in the 1-, 3- and 2-positions in neonatal and young animals has not previously been established. Therefore, the fate of orally administered 1-[1-C-14]palmitoyl, 2,3 dioleoyl glycerol ([C-14]POO) and 1,3 dioleoyl,2-[1-C-14]palmitoyl glycerol ([C-14]PO) was investigated in suckling and weanling rats using liquid scintillation counting of tissues and expired air and whole-body autoradiography. The results obtained indicate that orally administered [C-14]POO and O[C-14]PO are extensively absorbed from the gut, probably either as palmitic acid or as a palmitoyl glyceride in both suckling and weanling rats. Radioactivity initially concentrated in brown fat with apparent migration to the white fat of weanling rats by 96 h. Levels of C-14 were low in blood, brain and other tissues. Excretion of C-14 was mainly by expiration of CO2 (approximately 72% in 96 h), indicating P-oxidation as a major route of metabolism. Urine and faeces accounted for only approximately 6% of the excreted radioactivity. The design andsize of the experiment did not allow tests of statistical significance between the absorption and excretion of OPO and POO to be conducted. However, the absorption, distribution, beta -oxidation and excretion appeared to be similar. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:42:38