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Titolo:
Hox gene duplication and deployment in the annelid leech Helobdella
Autore:
Kourakis, MJ; Martindale, MQ;
Indirizzi:
Univ Chicago, Dept Organismal Biol & Anat, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 smal Biol & Anat, Chicago, IL 60637 USA
Titolo Testata:
EVOLUTION & DEVELOPMENT
fascicolo: 3, volume: 3, anno: 2001,
pagine: 145 - 153
SICI:
1520-541X(200105/06)3:3<145:HGDADI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; HOMEOBOX GENES; EVOLUTION; EXPRESSION; SEGMENTATION; ARTHROPODS; NEURONS; REGIONS; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Martindale, MQ Univ Hawaii, PBRC, Kewalo Marine Lab, 41 Ahui St, Honolulu,HI 96813 USA Univ Hawaii 41 Ahui St Honolulu HI USA 96813 , HI 96813 USA
Citazione:
M.J. Kourakis e M.Q. Martindale, "Hox gene duplication and deployment in the annelid leech Helobdella", EVOL DEV, 3(3), 2001, pp. 145-153

Abstract

The segmented leeches are members of the phylum Annelida within the Lophotrochozoa. Here, we describe the isolation of a new Hox gene, Lox18, in the leech Helobdella triserialis. Phylogenetic analysis indicates that Lox18 isa Deformed(Dfd) ortholog. H. triserialis has at least two Dfd orthologs, Lox18 and the previously described Lox6 (Kourakis et al. 1997; Wong and Macagno 1998), indicating that these genes duplicated after the last common ancestor of annelids and arthropods. Although the temporal appearance of Lox18message is similar to that of Lox6, the spatial pattern is different. Lox18 does not have a sharply defined anterior border of expression in the second neuromere of the subesophageal ganglion of the central nervous system (CNS) as does Lox6, but is expressed uniformly in a small subset of cells in the longitudinal connectives and lateral roots in every segment of the CNS along the entire anterior-posterior (AP) axis. Even though Lox18 shares greater sequence similarity within the homeodomain and flanking regions to Drosophila Dfd than to the previously isolated Lox6, its expression pattern suggests that its function has diverged from the ancestral Hox function. Previous sampling has indicated that the last common ancestor of protostomes and deuterostomes had as many as 10 clustered Hox genes representing distinctparalogy groups (Irvine et al. 1997; de Rosa et al. 1999); leech Hox genesmay have undergone subsequent and independent cluster or genome-wide duplication. These results point to the need for total genome level understanding for key members of the Lophotrochozoa.

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Documento generato il 22/01/20 alle ore 09:44:51