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Titolo:
Olanzapine in relapsing schizophrenia. Efficacy and serotonergic parameters
Autore:
Mooren, R; Verhoeven, WMA; Tuinier, S; van den Berg, YWMM; Fekkes, D; Pepplinkhuizen, L;
Indirizzi:
Vincent Van Gogh Inst Psychiat, NL-5803 AV Venray, Netherlands Vincent VanGogh Inst Psychiat Venray Netherlands NL-5803 AV Netherlands Erasmus Univ, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF PSYCHIATRY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 91 - 100
SICI:
0213-6163(200104/06)15:2<91:OIRSEA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE POLYMORPHIC PSYCHOSIS; NEGATIVE SYMPTOMS; DOUBLE-BLIND; HALOPERIDOL; TRIAL; ANTIPSYCHOTICS; DOPAMINE; PLACEBO; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Verhoeven, WMA Vincent Van Gogh Inst Psychiat, Stationsweg 46, NL-5803 AV Venray, Netherlands Vincent Van Gogh Inst Psychiat Stationsweg 46 Venray Netherlands NL-5803 AV
Citazione:
R. Mooren et al., "Olanzapine in relapsing schizophrenia. Efficacy and serotonergic parameters", EUR J PSYCH, 15(2), 2001, pp. 91-100

Abstract

In the present study, olanzapine was administered to 20 hospitalized schizophrenic patients with an acute episode of relapsing disease, following an open baseline controlled design. In addition to assessment of efficacy and safety, the effects of treatment on plasma levels of amino acids, 5-HT parameters and norharman were evaluated. Olanzapine induced antipsychotic effects without inducing any EPS and was associated with significant weight gainin a majority of patients. In half of the nonresponders, a subjective improvement of well being and general functioning was observed that could not be related to reduction of psychopathological features. Nonresponders appeared to present with clinically more severe arousal-like symptoms as assessedwith a subset of PANSS items. Non-response to treatment with olanzapine was found to be associated with lower 5-HT plasma concentrations at baseline and enhanced 5-HIAA plasma levels during the experimental period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:22:42