Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CD14(dim)/CD13(bright) monocytes in hemophagocytic lymphohistiocytosis
Autore:
Emminger, W; Zlabinger, GJ; Fritsch, G; Urbanek, R;
Indirizzi:
Univ Vienna, Childrens Hosp, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Childrens Hosp, A-1090 Vienna, Austria Univ Vienna, Inst Immunol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Inst Immunol, Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria StAnna Childrens Hosp Vienna Austria A-1090 nst, A-1090 Vienna, Austria
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 6, volume: 31, anno: 2001,
pagine: 1716 - 1719
SICI:
0014-2980(200106)31:6<1716:CMIHL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONOCYTES; MACROPHAGES; SUBSET; TH1;
Keywords:
CD14/16 monocyte; hemophagocytic lymphohistiocytosis; individual inflammatory state;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Emminger, W Univ Vienna, Childrens Hosp, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 tria
Citazione:
W. Emminger et al., "CD14(dim)/CD13(bright) monocytes in hemophagocytic lymphohistiocytosis", EUR J IMMUN, 31(6), 2001, pp. 1716-1719

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an extremely rare and highly lethal chronic inflammatory disease, which is mediated by proinflammatory cytokines. In the peripheral blood of a boy suffering from HLH, a chronic expansion of CDI4(dim)/CD16(bright) inflammatory monocytes was detected. Compared with CD14(bright) monocytes, their immunophenotype correlated with moremature monocytic cells differentiating to macrophages: they showed lower expression of CD11b, CD64 and CD35. Such CD14(dim)/CD16(bright) monocytes produce the inflammatory cytokines IL-1 beta, IL-6 and TNF-alpha. They fit inwell with the pathophysiological concept of HLH as an inflammatory state of lymphocytes and of the monocyte/macrophage system. In the presented patient the percentage of these circulating inflammatory monocytes decreased over time during clinical response to immunosuppressive therapy. This finding may indicate that CD14(dim)/CD16(bright) monocytes represented the degree of inflammation in this extremely rare and highly lethal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:35:23