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Titolo:
Hyaluronate and CD44 expression patterns in the human placenta throughout pregnancy
Autore:
Marzioni, D; Crescimanno, C; Zaccheo, D; Coppari, R; Underhill, CB; Castellucci, M;
Indirizzi:
Univ Ancona, Inst Normal Human Morphol, Ancona, Italy Univ Ancona AnconaItaly cona, Inst Normal Human Morphol, Ancona, Italy Univ Verona, Inst Human Anat & Histol, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 an Anat & Histol, I-37100 Verona, Italy Univ Genoa, Inst Anat, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Inst Anat, Genoa, Italy Georgetown Univ, Med Ctr, Dept Anat & Cell Biol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 ll Biol, Washington, DC 20007 USA
Titolo Testata:
EUROPEAN JOURNAL OF HISTOCHEMISTRY
fascicolo: 2, volume: 45, anno: 2001,
pagine: 131 - 140
SICI:
1121-760X(2001)45:2<131:HACEPI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
METASTASIS-ASSOCIATED VARIANT; CELL-ADHESION; RECEPTOR; BINDING; ARCHITECTURE; LOCALIZATION; CARCINOMA; MIGRATION; PROTEIN; HOMOLOG;
Keywords:
hyaluronan; CD44; human placenta; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Castellucci, M Univ Ancona, Inst Normal Human Morphol, Ancona, Italy Univ Ancona Ancona Italy al Human Morphol, Ancona, Italy
Citazione:
D. Marzioni et al., "Hyaluronate and CD44 expression patterns in the human placenta throughout pregnancy", EUR J HIST, 45(2), 2001, pp. 131-140

Abstract

Hyaluronan (HA) and CD44 are involved in several processes such as cell migration and differentiation. In the present study, we examined the expression and distribution of both hyaluronan and its cell surface receptor (CD44)in the human placenta, which is a rapidly growing and differentiating organ that plays a fundamental role in fetal;life. Hyaluronan was detected by aspecific biotinylated binding probe, termed b-PG. In the first half of gestation, HA was strongly expressed in the stroma of the mesenchymal villi which have been previously identified as responsible for the growth and differentation of the villous trees. The other villous types showed an intense staining only in the fetal vessel walls and in the connective tissue closelyunderlying the trophoblastic cover. In addition, hyaluronan positive staining was also apparent in a restricted rim of villous stroma directly apposed to extravillous cytotrophoblastic cell islands and eel columns. In full term placentas, all villi expressed HA in their stromal tissue with a more homogenous staining than in the first half of gestation. In contrast to hyaluronan, in the first trimester CD44 was restricted to some of the Hofbauer cells which may be able to internalize hyaluronan, thus playing a significant role in its removal in early pregnancy. CD44 was primarily expressed starting from the 16(th) week of gestation. At the end of pregnancy it was expressed in the Various villous types, especially in stem villi. Moreover, the plasma membrane of some extravillous cytotrophoblastic cells in the basalplate and the large majority of the decidual cells showed a positive immunostaining for this receptor. Taken together, these data suggest that HA is strongly involved in early villous morphogenesis, whereas CD44 seem to be play an important role in tissue remodelling later in gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:53:17