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Titolo:
Clinical characteristics and outcome of patients with invasive pneumococcal disease, Puy-de-Dome, France, 1994-1998
Autore:
Laurichesse, H; Romaszko, JP; Nguyen, LT; Souweine, B; Poirier, V; Guelon, D; Andre, M; Ruivard, M; De Champs, C; Caillaud, D; Labbe, A; Beytout, J;
Indirizzi:
Univ Hosp Clermont Ferrand, Bacteriol Lab, Clermont Ferrand, France Univ Hosp Clermont Ferrand Clermont Ferrand France mont Ferrand, France Univ Hosp Clermont Ferrand, Gabriel Montpied Hosp, Dept Pulm Dis, ClermontFerrand, France Univ Hosp Clermont Ferrand Clermont Ferrand France rmontFerrand, France Univ Hosp Clermont Ferrand, Gabriel Montpied Hosp, Intens Care Unit, Clermont Ferrand, France Univ Hosp Clermont Ferrand Clermont Ferrand France mont Ferrand, France Univ Hosp Clermont Ferrand, Hotel Dieu, Pediat Dis Dept, Clermont Ferrand,France Univ Hosp Clermont Ferrand Clermont Ferrand France rmont Ferrand,France Univ Hosp Clermont Ferrand, Hotel Dieu, Dept Infect Dis, F-63000 Clermont Ferrand, France Univ Hosp Clermont Ferrand Clermont Ferrand France F-63000 rrand, France Univ Hosp Clermont Ferrand, Gabriel Montpied Hosp, Dept Anesthesiol & Reanimat, Clermont Ferrand, France Univ Hosp Clermont Ferrand Clermont Ferrand France mont Ferrand, France Univ Hosp Clermont Ferrand, Gabriel Montpied Hosp, Dept Internal Med, Clermont Ferrand, France Univ Hosp Clermont Ferrand Clermont Ferrand France mont Ferrand, France Univ Hosp Clermont Ferrand, Hotel Dieu, Dept Internal Med, Clermont Ferrand, France Univ Hosp Clermont Ferrand Clermont Ferrand France mont Ferrand, France
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
fascicolo: 5, volume: 20, anno: 2001,
pagine: 299 - 308
SICI:
0934-9723(200105)20:5<299:CCAOOP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMUNITY-ACQUIRED PNEUMONIA; RESISTANT STREPTOCOCCUS-PNEUMONIAE; RISK-FACTORS; POLYSACCHARIDE VACCINE; ANTIMICROBIAL RESISTANCE; PENICILLIN-RESISTANCE; ANTIBIOTIC-RESISTANCE; DEVELOPED-COUNTRIES; CONJUGATE VACCINE; DRUG-RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Laurichesse, H CHU Clermont Ferrand, Hotel Dieu, Serv Malad Infect & Trop,BP69, F-63000 Clermont Ferrand 01, France CHU Clermont Ferrand BP69 Clermont Ferrand France 01 rance
Citazione:
H. Laurichesse et al., "Clinical characteristics and outcome of patients with invasive pneumococcal disease, Puy-de-Dome, France, 1994-1998", EUR J CL M, 20(5), 2001, pp. 299-308

Abstract

A surveillance program for invasive pneumococcal disease was undertaken inPuy-de-Dome, an administrative district of the region Auvergne in France, from 1 January 1994 to 31 December 1998. A total of 214 cases were identified. The annual incidence of invasive pneumococcal disease increased (P=0.04) from 5.5 in 1994 to 9.3 cases per 10(5) person-years in 1998. The highestincidences were for children <2 years of age (59.2 cases per 10(5) person-years) and for adults greater than or equal to 65 years (18 cases per 10(5)person-years). Clinical diagnoses, available in 200 patients, included acute pneumonia (62%), meningitis (10%), sepsis without focus (20%), and others (8%). The most frequent chronic medical conditions of the patients included smoking, alcoholism, cardiovascular and pulmonary diseases, and malignancies. Thirty-one percent of the isolates were nonsusceptible to penicillin. Penicillin resistance (MIC greater than or equal to0.1 mg/l) was more frequent (P=0.02) in cancer patients. The overall case-fatality rate was 21.5%. Risk factors for death were age, sex, and underlying diseases of the patients, along with the severity of illness. These population-based findings should convince clinicians to offer pneumococcal vaccine to patients at high risk for invasive pneumococcal disease, thereby increasing vaccination coverage levels in France.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:49:50