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Titolo:
Ischaemia, reperfusion and cardioprotection: successes and failures in thejourney from molecule to main
Autore:
Hearse, DJ;
Indirizzi:
St Thomas Hosp, Rayne Inst, London SE1 7EH, England St Thomas Hosp London England SE1 7EH ayne Inst, London SE1 7EH, England
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: C, volume: 3, anno: 2001,
pagine: C11 - C21
SICI:
1520-765X(200106)3:C<C11:IRACSA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT-HEART; VITAMIN-E CONSUMPTION; INDUCED ARRHYTHMIAS; ISCHEMIC CONTRACTURE; ANTIOXIDANT THERAPY; DISEASE; INJURY; PROTECTION; MYOCARDIUM; CARDIOPLEGIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hearse, DJ St Thomas Hosp, Rayne Inst, London SE1 7EH, England St Thomas Hosp London England SE1 7EH London SE1 7EH, England
Citazione:
D.J. Hearse, "Ischaemia, reperfusion and cardioprotection: successes and failures in thejourney from molecule to main", EUR H J SUP, 3(C), 2001, pp. C11-C21

Abstract

In response to the increasing toll of ischaemic heart disease, the last 50years have seen an enormous amount of research aimed at understanding the biology of ischaemia and developing methods to control it. Much of this research has used animal models; in some instances the findings have been translated successfully to man, in others they have failed to apply to human ischaemia. Some of the failures may be due to animal models inadequately mimicking the clinical situation-a problem arising from there being is no consensus on a definition of ischaemia. Despite these difficulties, laboratory research has led to a detailed molecular and cellular characterization of experimental ischaemia. From this has emerged the concept of cardioprotection: identifying key changes in the progression of ischaemic injury and developing anti-ischaemic agents to combat these changes, thereby increasing the tolerance of the heart to ischaemia. Effective cardioprotection has been established in the laboratory and has been translated very successfully to man in the arena of cardiac surgery. Unfortunately, because of fundamental conceptual flaws, the application of anti-ischaemic therapy to management of evolving myocardial infarction has, so far, failed. Laboratory research has revealed the phenomenon of reperfusion injury and,in doing so, established the importance of free radicals and oxidant stress in the genesis of injury during ischaemia and reperfusion. From this, theconcept of limiting reperfusion injury has emerged and surgeons have againexploited this concept for the benefit of patients, although cardiologistsappear reluctant to combine such an approach with thrombolysis. Recent research has also revealed the remarkable adaptive powers of the heart and its ability to increase its tolerance to ischaemia through phenomena such as preconditioning. Although preconditioning undoubtedly occurs in man, many hurdles must be overcome before this alternative approach to cardioprotection can impact the management of heart disease. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:54:06