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Titolo:
Relationship between thyroid function and skeletal muscle involvement in subclinical and overt hypothyroidism
Autore:
Hartl, E; Finsterer, J; Grossegger, C; Kroiss, A; Stollberger, C;
Indirizzi:
Krankenanstalt Rudolfstiftung, Internal Dept 2, Vienna, Austria Krankenanstalt Rudolfstiftung Vienna Austria al Dept 2, Vienna, Austria Krankenanstalt Rudolfstiftung, Dept Nucl Med, Vienna, Austria Krankenanstalt Rudolfstiftung Vienna Austria Nucl Med, Vienna, Austria Ludwig Boltzmann Inst Res Neuromuscular Disorders, Vienna, Austria Ludwig Boltzmann Inst Res Neuromuscular Disorders Vienna Austria ustria
Titolo Testata:
ENDOCRINOLOGIST
fascicolo: 3, volume: 11, anno: 2001,
pagine: 217 - 221
SICI:
1051-2144(200105/06)11:3<217:RBTFAS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATINE-KINASE; NEUROMUSCULAR FINDINGS; MYOPATHY; DYSFUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Finsterer, J Postfach 348, A-1180 Vienna, Austria Postfach 348 Vienna Austria A-1180 , A-1180 Vienna, Austria
Citazione:
E. Hartl et al., "Relationship between thyroid function and skeletal muscle involvement in subclinical and overt hypothyroidism", ENDOCRINOLO, 11(3), 2001, pp. 217-221

Abstract

It is not well known how often the skeletal muscle is involved in hypothyroidism and if there is a relation between the severity of hypothyroidism and the degree of skeletal muscle involvement. This prospective, observational study investigated the frequency of muscle symptoms, symptoms of hypothyroidism, elevated serum creatine kinase (CK) and the relation between CK andthyroid function tests, During 6 months, 69 patients, aged 16-87 years, inwhom hypothyroidism was newly diagnosed were studied, Sixty one patients had subclinical and eight had overt hypothyroidism. Twenty five percent had muscle symptoms. Muscle symptoms were observed in 16 patients with subclinical and 1 patient with overt hypothyroidism. Symptoms of hypothyroidism were equally frequent in patients with (82%) and without (88%) muscle symptoms. CK was elevated in 3%. CK levels were not related to any of the thyroid function tests. In conclusion, the relation between the degree of skeletal muscle involvement and the severity of hypothyroidism in patients with subclinical and overt hypothyroidism is poor. CK is only rarely elevated in these patients. The skeletal muscle is less frequently involved in patients with hypothyroidism than previously reported.

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Documento generato il 09/07/20 alle ore 17:35:30