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Titolo:
Pituitary-adrenal physiology during pregnancy
Autore:
Keller-Wood, M; Wood, CE;
Indirizzi:
Univ Florida, Coll Pharm, Dept Pharmacodynam, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 acodynam, Gainesville, FL 32610 USA Univ Florida, Coll Med, Dept Physiol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Physiol, Gainesville, FL 32610 USA
Titolo Testata:
ENDOCRINOLOGIST
fascicolo: 3, volume: 11, anno: 2001,
pagine: 159 - 170
SICI:
1051-2144(200105/06)11:3<159:PPDP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-HORMONE; FETAL-PLACENTAL CIRCULATION; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; INSULIN-INDUCED HYPOGLYCEMIA; FACTOR-BINDING PROTEIN; UMBILICAL-CORD PLASMA; MATERNAL PLASMA; RHESUS-MONKEY; MESSENGER-RNA; ARGININE-VASOPRESSIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
170
Recensione:
Indirizzi per estratti:
Indirizzo: Keller-Wood, M Univ Florida, Coll Pharm, Dept Pharmacodynam, Box 100487, Gainesville, FL 32610 USA Univ Florida Box 100487 Gainesville FL USA 32610 32610 USA
Citazione:
M. Keller-Wood e C.E. Wood, "Pituitary-adrenal physiology during pregnancy", ENDOCRINOLO, 11(3), 2001, pp. 159-170

Abstract

In many species, including human beings, pregnancy results in an activation of the hypothalamus-pituitary-adrenal (HPA) axis, resulting in increased maternal cortisol secretion. This increase is important for maintaining an environment to support fetal growth and development, because adrenal excessor insufficiency results in disturbances in maternal and fetal homeostasis. The mechanism of the HPA axis activation is not completely understood, and in the human, may involve placental secretion of corticotropin releasing hormone. However, a common mechanism is likely to be the interaction of progesterone with mineralocorticoid receptors in the brain, resulting in an increase in set-point for cortisol. In the human, maternal cortisol can crossthe placenta and affect fetal physiology before the fetal adrenal maturation. As the fetus matures, transplacental passage of cortisol decreases, endthe fetal adrenal cortisol and androgen secretion increases. The maturing fetal HPA. axis ultimately controls the timing of parturition by determining the rate of estrogen secretion from the placenta, thereby stimulating increased myometrial activity during labor, At term, interactions between the HPA and placental hormones may result in positive feedback cycles, which amplify and coordinate the increases in HPA secretion, myometrial activity, and fetal organ maturation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:25:32