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Titolo:
The cadherin-catenin superfamily in endocrine tumors
Autore:
Semba, S; Yamakawa, M; Sasano, H;
Indirizzi:
Yamagata Univ, Sch Med, Dept Pathol 1, Yamagata 9909585, Japan Yamagata Univ Yamagata Japan 9909585 t Pathol 1, Yamagata 9909585, Japan Tohoku Univ Hosp, Dept Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Hosp Sendai Miyagi Japan 9808575 endai, Miyagi 9808575, Japan
Titolo Testata:
ENDOCRINE PATHOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 1 - 13
SICI:
1046-3976(200121)12:1<1:TCSIET>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; MAMMARY EPITHELIAL-CELLS; BETA-CATENIN; ALPHA-CATENIN; HUMAN BREAST; TYROSINE PHOSPHORYLATION; EARLY EMBRYOGENESIS; SUPPRESSOR PROTEIN; THYROID CARCINOMAS; COLORECTAL-CANCER;
Keywords:
cadheri-ctenin superfamily; E-cadherin; beta-catenin; endocrine tumors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Semba, S Yamagata Univ, Sch Med, Dept Pathol 1, 2-2-2 Iida Nishi, Yamagata9909585,Japan Yamagata Univ 2-2-2 Iida Nishi Yamagata Japan 9909585 9585,Japan
Citazione:
S. Semba et al., "The cadherin-catenin superfamily in endocrine tumors", ENDOCR PATH, 12(1), 2001, pp. 1-13

Abstract

It has been well-known that the cadherin-catenin complexes bind with intracellular skeleton actin, which result in stabilization of cellular structure and tissue organization. Therefore, the cadherin-catenin family has been considered prerequisite for normal cell function and the preservation of tissue integrity. In human malignancies especially colon cancers, dysfunctionand/or decrease of expression of these proteins have been proposed to prevent differentiation of tumors and to increase invasiveness and poor prognosis. However, recent studies also revealed that a mem ber of this superfamily, beta -catenin, may play an important role in Wnt/wingless intracellular signaling pathway. Decreased expression of this protein or somatic mutationof the beta -catenin gene has been also reported in human carcinomas including various endocrine tumors. Mutant beta -catenin is associated with abnormal nuclear accumulation in tumor cells and subsequently to activate othertranscription factors such as Tcf/Lef. This activation eventually results in which upregulation of mRNA and protein levels of various cell growth mediators in these endocrine tumors. Therefore, dysfunction of the cadherin-catenin system is considered to be closely correlated with tumorigenesis and development in human endocrine tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:16:14