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Titolo:
Ovarian hormones elicit phosphorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex
Autore:
Singh, M;
Indirizzi:
Columbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032USA Columbia Univ New York NY USA 10032 stet & Gynecol, New York, NY 10032USA Columbia Univ, Coll Phys & Surg, Ctr Reprod Sci, New York, NY 10032 USA Columbia Univ New York NY USA 10032 tr Reprod Sci, New York, NY 10032 USA
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 407 - 415
SICI:
1355-008X(200104)14:3<407:OHEPOA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; NERVE GROWTH-FACTOR; AMYLOID (25-35)-INDUCED TOXICITY; ESTROGEN-INDUCED ACTIVATION; NEWBORN MOUSE HYPOTHALAMUS; PRIMARY CORTICAL-NEURONS; PREOPTIC AREA INVITRO; RIBOSOMAL S6 KINASE; SPRAGUE-DAWLEY RATS; CELL-DEATH;
Keywords:
progesterone; estrogen; Akt; extracellular-signal regulated kinase; neuroprotection; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, M Columbia Univ, Coll Phys & Surg, Dept Obstet & Gynecol, 650 W 168th St,Black Bldg 1615, New York, NY 10032 USA Columbia Univ 650 W 168th St,Black Bldg 1615 New York NY USA 10032
Citazione:
M. Singh, "Ovarian hormones elicit phosphorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex", ENDOCRINE, 14(3), 2001, pp. 407-415

Abstract

Estradiol and progesterone both have been demonstrated to afford neuroprotection against various insults. In an attempt to identify potential mechanisms underlying these neuroprotective effects, two key elements within signal transduction pathways linked to neuroprotection were evaluated. In mouse cerebral cortical explants, both estradiol and progesterone elicited the phosphorylation of Akt, a downstream effector of the phosphoinositide-3 (PI-3) kinase pathway. Progesterone also elicited the phosphorylation of extracellular-signal regulated kinase (ERK), a component of the mitogen-activated protein kinase (MAPK) pathway. These effects were not inhibited by the progesterone receptor antagonist, RU486. However, inhibition of either MAPK/ERKkinase with PD98059 or PI-3 kinase with LY294002 successfully inhibited progesterone's actions on ERK and Akt, respectively. Collectively, the data offer novel mechanisms for both progesterone and estrogen action in the central nervous system, demonstrating the functional and mechanistic diversity of gonadal hormones and supporting their neuroprotective potential for suchneurodegenerative disorders as Alzheimer disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:33:28