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Titolo:
Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin, prohormone convertase-1, prohormone convertase-2, and glucocorticoid receptor mRNA in fetal sheep
Autore:
Holloway, AC; Whittle, WL; Challis, JRG;
Indirizzi:
Univ Toronto, Dept Physiol, MRC, Grp Fetal & Neonatal Hlth & Dev, Toronto,ON, Canada Univ Toronto Toronto ON Canada & Neonatal Hlth & Dev, Toronto,ON, Canada Univ Toronto, Dept Obstet & Gynecol, MRC, Grp Fetal & Neonatal Hlth & Dev,Toronto, ON, Canada Univ Toronto Toronto ON Canada & Neonatal Hlth & Dev,Toronto, ON, Canada
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 343 - 348
SICI:
1355-008X(200104)14:3<343:EOCAEO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; OVINE FETUS; GENE-EXPRESSION; ACTH-SECRETION; PARTURITION; GESTATION; RNA; ESTROGEN; BRAIN; ONSET;
Keywords:
proopiomelanocortin; prohormone convertase-1; glucocorticoid receptor; adrenocorticotropic hormone; cortisol; estradiol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Holloway, AC Univ Toronto, Dept Physiol, MRC, Grp Fetal & Neonatal Hlth & Dev, 1 Kings Coll Circle, Toronto, ON, Canada Univ Toronto 1 Kings Coll Circle Toronto ON Canada N, Canada
Citazione:
A.C. Holloway et al., "Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin, prohormone convertase-1, prohormone convertase-2, and glucocorticoid receptor mRNA in fetal sheep", ENDOCRINE, 14(3), 2001, pp. 343-348

Abstract

We hypothesized that in the late-gestation sheep fetus there is an interaction between the prepartum rise in cortisol and the increase in placental estradiol production that allows expression of key components of the fetal hypothalamic-pituitary-adrenal (HPA) axis. Therefore, the goal of this studywas to investigate the effects of cortisol on the fetal HPA axis in the presence and absence of increased placental estradiol production. We obtainedfetal plasma samples and pituitary tissue from animals that had received an infusion of either cortisol, cortisol and 4-hydroxyandrostenedione (4OHA,an aromatase inhibitor), saline, or saline + 4OHA controls. Cortisol significantly decreased plasma adrenocorticotropic hormone concentrations, and in the presence of 4OHA reduced pituitary proopiomelanocortin (POMC) mRNA levels in the pars distalis. There was no effect of any treatment on the expression of the key POMC processing enzymes, prohormone convertase-1 or -2 inthe fetal pituitary. Conversely, levels of glucocorticoid receptor (GR) mRNA in the pituitary were increased with cortisol treatment in the absence of increased estradiol. We suggest that in the late-gestation sheep fetus, cortisol and estradiol have opposite effects on pituitary POMC and GR mRNA expression, and interact to regulate these key components of the fetal HPA axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:45:19