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Titolo:
Sustained activity of luteal cytosolic phospholipase A(2) during luteolysis in pseudopregnant rats - Its possible implication in tissue involution
Autore:
Kurusu, S; Sakaguchi, S; Kawaminami, M; Hashimoto, I;
Indirizzi:
Kitasato Univ, Sch Vet Med & Anim Sci, Physiol Lab, Towada, Aomori 0348628, Japan Kitasato Univ Towada Aomori Japan 0348628 , Towada, Aomori 0348628, Japan
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 337 - 342
SICI:
1355-008X(200104)14:3<337:SAOLCP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORPUS-LUTEUM; INDUCED APOPTOSIS; PLASMA-MEMBRANE; PROLACTIN; PROSTAGLANDINS; EXPRESSION; OVARY; CELLS; PROLIFERATION; INVOLVEMENT;
Keywords:
cytosolic phospholipase A(2); luteolysis; rat; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kurusu, S Kitasato Univ, Sch Vet Med & Anim Sci, Physiol Lab, Towada, Aomori 0348628, Japan Kitasato Univ Towada Aomori Japan 0348628 Aomori 0348628, Japan
Citazione:
S. Kurusu et al., "Sustained activity of luteal cytosolic phospholipase A(2) during luteolysis in pseudopregnant rats - Its possible implication in tissue involution", ENDOCRINE, 14(3), 2001, pp. 337-342

Abstract

We investigated the expression and activity of cytosolic phospholipase A(2) (cPLA(2)) in the corpus luteum during spontaneous and induced luteolysis in pseudopregnant rats. In both models, luteal PLA(2) activity rose in association with functional regression and persisted during the following structural regression. Tissue concentration of prostaglandin F-2 alpha with a luteolytic potency showed a similar fluctuation. The enzyme activity was almost completely suppressed by a cPLA(2)-specific inhibitor. Expression of cPLA(2), analyzed by immunohistochemistry, became enhanced during luteolysis with preferential localization to phagocytotic and fibrotic replacement sites. Taken together with our previous finding, the data indicate a persistentelevation in luteal cPLA(2) expression and activity that may affect tissueinvolution in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:21:50