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Titolo:
Regulation of insulin-stimulated tyrosine phosphorylation of Shc and Shc/Grb2 association in liver, muscle, and adipose tissue of epinephrine- and streptozotocin-treated rats
Autore:
Paez-Espinosa, V; Rocha, EM; Velloso, LA; Saad, MJA;
Indirizzi:
Univ Estadual Campinas, UNICAMP, Fac Ciencias Med, Dept Clin Med, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13081970 BCpinas, SP, Brazil Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Fisiol & Biofis, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13081970 BCpinas, SP, Brazil
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 295 - 302
SICI:
1355-008X(200104)14:3<295:ROITPO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOGENIC SIGNAL-TRANSDUCTION; RECEPTOR SUBSTRATE FAMILY; ACTIVATED PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOTYROSINE PROTEIN; GROWTH-HORMONE; DIABETIC RATS; DOMAIN; IRS-1; CELLS;
Keywords:
epinephrine; diabetes mellitus; streptozotocin; insulin receptor substrate-1; Shc; Shc-Grb2 association;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Saad, MJA Univ Estadual Campinas, UNICAMP, Fac Ciencias Med, Dept Clin Med, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13081970 BC Brazil
Citazione:
V. Paez-Espinosa et al., "Regulation of insulin-stimulated tyrosine phosphorylation of Shc and Shc/Grb2 association in liver, muscle, and adipose tissue of epinephrine- and streptozotocin-treated rats", ENDOCRINE, 14(3), 2001, pp. 295-302

Abstract

Shc protein phosphorylation has been extensively characterized as the initial step that activates a complex mitogenic pathway through its associationwith Grh2. In the present study, we investigated the adrenergic control ofinsulin-induced She phosphorylation and Shc-Grb2 association, and the modulating effect of streptozotocin-induced diabetes mellitus on She phosphorylation and Shc/Grb2 association. Acute treatment with epinephrine, which leads to a normoglycemic insulin-resistant state, does not affect insulin-induced She tyrosine phosphorylation or Shc-Grb2 association in liver, muscle, or fat. By contrast, a significant increase in insulin-induced She phosphorylation is observed in liver and muscle of rats treated with streptozotocin. The association of Shc/Grb2 is also increased in both tissues following insulin treatment, These data suggest that while epinephrine preserves the insulin/induced phosphorylation of She and the mitogenic pathway stimulated by Shc-Grb2 association, treatment with streptozotocin leads to a tissue-specific increase in the activity of the initial step that ultimately resultsin the activation of the Shc/Grb2 mitogenic pathway.

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Documento generato il 08/08/20 alle ore 08:40:42