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Titolo:
Human leucocyte interferon-alpha in the treatment of chronic hepatitis C
Autore:
Mazzoran, L; Zorat, F; Chemello, L; Croce, LS; Rigato, I; Cavalletto, L; Bernardinello, E; Tiribelli, C; Alberti, A; Pozzato, G;
Indirizzi:
Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, CSF, I-34127 Trieste, Italy Univ Trieste Trieste Italy I-34127 Macromol, CSF, I-34127 Trieste, Italy Univ Padua, Sch Med, Dept Clin & Expt Med, Padua, Italy Univ Padua PaduaItaly dua, Sch Med, Dept Clin & Expt Med, Padua, Italy Univ Trieste, Sch Med, Inst Internal Med, Trieste, Italy Univ Trieste Trieste Italy , Sch Med, Inst Internal Med, Trieste, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 4, volume: 33, anno: 2001,
pagine: 347 - 352
SICI:
1590-8658(200105)33:4<347:HLIITT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAIRY-CELL LEUKEMIA; RANDOMIZED TRIAL; DIFFERENT REGIMENS; VIRAL-HEPATITIS; VIRUS-INFECTION; NON-A; NON-B; THERAPY; EFFICACY; ALFA;
Keywords:
antiviral therapy; chronic hepatitis C; human leucocyte interferon alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pozzato, G Osped Gattinara, Ist Med Clin, Strada Fiume 447, I-34149 Trieste, Italy Osped Gattinara Strada Fiume 447 Trieste Italy I-34149 , Italy
Citazione:
L. Mazzoran et al., "Human leucocyte interferon-alpha in the treatment of chronic hepatitis C", DIG LIVER D, 33(4), 2001, pp. 347-352

Abstract

Aim. To assess the efficacy of different schedules of human leucocyte interferon a in chronic hepatitis C. Patients and Methods. A total of 213 naive patients with chronic hepatitisC were treated with 4 different schedules of human leucocyte interferon alpha. Sustained response was defined as persistently normal alanine amino transferase values with negative serum hepatitis C virus-RNA up to 12 months after therapy withdrawal. Results. Rates of sustained response were 16% with 3 MU tiw for 6 months, 33% with 6 MU tiw for 5 months after a priming dose of 9 MU tiw for a month, 32% with 3 MU tiw for 12 months and 20% with 3 MU daily for 6 months. Themajor factors affecting the response rate were age and the hepatitis C Virus genotype, as a sustained response was significantly higher in patients under 45 years and infected by hepatitis 6 virus types other than hepatitis C virus-1. Treatment was well tolerated and side-effects and drop-out events were similar to those described with other types of alpha -interferons. Conclusions. Human leucocyte interferon ct appears to be equivalent to recombinant interferon-alpha in the treatment of chronic hepatitis C.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:24:02