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Titolo:
Evaluation of the association between serum anti-Lewis X antibody and inflammatory infiltration into the gastric mucose infected with Helicobacter pylori
Autore:
Shimoyama, T; Fukuda, S; Tanaka, M; Nakaji, S; Fukuda, Y; Munakata, A;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Internal Med 1, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Dept Pathol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Dept Hyg, Hirosaki, Aomori 0368562, Japan HirosakiUniv Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hyogo Coll Med, Dept Internal Med 4, Nishinomiya, Hyogo, Japan Hyogo Coll Med Nishinomiya Hyogo Japan Med 4, Nishinomiya, Hyogo, Japan
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 4, volume: 33, anno: 2001,
pagine: 326 - 329
SICI:
1590-8658(200105)33:4<326:EOTABS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR MIMICRY; JAPANESE PATIENTS; EXPRESSION; CANCER; LIPOPOLYSACCHARIDE; AUTOIMMUNITY; CARCINOMA; HOST;
Keywords:
gastritis; Helicobacter pylori; Lewis X;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Shimoyama, T Hirosaki Univ, Sch Med, Dept Internal Med 1, 5 Zaifu Cho, Hirosaki, Aomori0368562, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan0368562 Japan
Citazione:
T. Shimoyama et al., "Evaluation of the association between serum anti-Lewis X antibody and inflammatory infiltration into the gastric mucose infected with Helicobacter pylori", DIG LIVER D, 33(4), 2001, pp. 326-329

Abstract

Background, Lipopolysaccharides of Helicobacter pylori have an antigenic structure that mimics Lewis X occurring in gastric mucose. The pathogenic role of antigenic mimicry in Helicobacter pylori-induced gastritis has been of recent interest. Aim, To examine whether this molecular mimicry affects gastric mucosal inflammation in patients infected with Helicobacter pylori. Patients, A total of 59 patients (mean age 58.0 years, 35 males, 24 females) were studied. Methods, Serum samples were collected to measure IgG antibodies to Helicobacter pylori and Lewis X. Biopsy specimens were obtained from the antrum and corpus for the grading of gastritis. Correlation coefficients between serum Lewis X antibody titre and histological grades of inflammatory infiltration were determined. Results. There was no significant correlation between anti-Lewis X antibody titre and the grade of mononuclear or polymorphonuclear cell infiltration. High titre of anti-Lewis X antibody was seen only in patients who had increased inflammatory infiltration in the corpus. Conclusions. Serum anti-Lewis X antibody, possibly induced by Helicobacterpylori infection, does not seem to play a major role in gastric mucosal inflammation in patients with Helicobacter pylori infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 16:07:55