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Titolo:
DBHR, a gene with homology to dopamine beta-hydroxylase, is expressed in the neural crest throughout early development
Autore:
Knecht, AK; Bronner-Fraser, M;
Indirizzi:
CALTECH, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Div Biol, Pasadena, CA 91125 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 234, anno: 2001,
pagine: 365 - 375
SICI:
0012-1606(20010615)234:2<365:DAGWHT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERTEBRATE HEAD; HOX CODE; HINDBRAIN; CELLS; PLASTICITY; RHOMBOMERE; MIGRATION; NEURONS; CHICK; MONOOXYGENASE;
Keywords:
DBHR; MOX; monooxygenase; dopamine-beta-hydroxylase (DBH); chick development; neural crest; hindbrain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Bronner-Fraser, M CALTECH, Div Biol, 139-74, Pasadena, CA 91125 USA CALTECH 139-74 Pasadena CA USA 91125 adena, CA 91125 USA
Citazione:
A.K. Knecht e M. Bronner-Fraser, "DBHR, a gene with homology to dopamine beta-hydroxylase, is expressed in the neural crest throughout early development", DEVELOP BIO, 234(2), 2001, pp. 365-375

Abstract

In a screen for genes involved in neural crest development, we identified DBHR (DBH-Related), a putative monooxygenase with low homology to dopamine beta -hydroxylase (DBH). Here, we describe novel expression patterns for DBHR in the developing embryo and particularly the neural crest. DBHR is an early marker for prospective neural crest, with earliest expression at the neural plate border where neural crest is induced, furthermore, DBHR expression persists in migrating neural crest and in many, though not all, crest derivatives. DBHR is also expressed in the myotome, from the earliest stagesof its formation, and in distinct regions of the neural tube, including even-numbered rhombomeres of the hindbrain. In order to investigate the signals that regulate its segmented pattern in the hindbrain, we microsurgicallyrotated the rostrocaudal positions of rhombomeres 3/4. Despite their ectopic position, both rhombomeres continued to express DBHR at the level appropriate for their original location, indicating that DBHR is regulated autonomously within rhombomeres. We conclude that DBHR is a divergent member of agrowing family of DBH-related genes; thus, DBHR represents a completely new type of neural crest marker, expressed throughout the development of the neural crest, with possible functions in cell-cell signaling. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:09:50