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Titolo:
Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan
Autore:
Tolwinski, NS; Wieschaus, E;
Indirizzi:
Princeton Univ, Dept Mol Biol, Howard Hughes Med Inst, Princeton, NJ 08544USA Princeton Univ Princeton NJ USA 08544 es Med Inst, Princeton, NJ 08544USA
Titolo Testata:
DEVELOPMENT
fascicolo: 11, volume: 128, anno: 2001,
pagine: 2107 - 2117
SICI:
0950-1991(200106)128:11<2107:ANIIRB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; DROSOPHILA HOMOLOG; WINGLESS SIGNAL; CELL-ADHESION; NEGATIVE REGULATION; WNT PATHWAY; E-CADHERIN; LOCALIZATION; PLAKOGLOBIN; POLARITY;
Keywords:
Wnt/wingless; armadillo; nuclear import/export; Drosophila melanogaster;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Wieschaus, E Princeton Univ, Dept Mol Biol, Howard Hughes Med Inst, Princeton, NJ 08544USA Princeton Univ Princeton NJ USA 08544 Princeton, NJ 08544USA
Citazione:
N.S. Tolwinski e E. Wieschaus, "Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan", DEVELOPMENT, 128(11), 2001, pp. 2107-2117

Abstract

Drosophila melanogaster Armadillo plays two distinct roles during development. It is a component of adherens junctions, and functions as a transcriptional activator in response to Wingless signaling. In the current model, Wingless signal causes stabilization of cytoplasmic Armadillo allowing it to enter the nucleus where it can activate transcription. However, the mechanism of nuclear import and export remains to be elucidated. In this study, weshow that two gain-of-function alleles of Armadillo activate Wingless signaling by different mechanisms. The S10 allele was previously found to localize to the nucleus, where it activates transcription. In contrast, the Delta Arm allele localizes to the plasma membrane, and forces endogenous Arm into the nucleus. Therefore, Delta Arm is dependent on the presence of a functional endogenous allele of arm to activate transcription. We show that Delta Arm may function by titrating Axin protein to the membrane, suggesting that it acts as a cytoplasmic anchor keeping Arm out of the nucleus. In axinmutants, Arm is localized to the nuclei, We find that nuclear retention isdependent on dTCF/Pangolin, This suggests that cellular distribution of Arm is controlled by an anchoring system, where various nuclear and cytoplasmic binding partners determine its localization.

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Documento generato il 30/03/20 alle ore 18:56:21