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Titolo:
Concentrations of hepatocyte growth factor in cerebrospinal fluid under normal and different pathological conditions
Autore:
Kern, MA; Bamborschke, S; Nekic, M; Schubert, D; Rydin, C; Lindholm, D; Schirmacher, P;
Indirizzi:
Univ Cologne, Inst Pathol, D-50931 Cologne, Germany Univ Cologne CologneGermany D-50931 st Pathol, D-50931 Cologne, Germany Univ Cologne, Dept Neurol, D-50931 Cologne, Germany Univ Cologne CologneGermany D-50931 pt Neurol, D-50931 Cologne, Germany Univ Uppsala, Dept Neurosci, S-75123 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75123 pt Neurosci, S-75123 Uppsala, Sweden
Titolo Testata:
CYTOKINE
fascicolo: 3, volume: 14, anno: 2001,
pagine: 170 - 176
SICI:
1043-4666(20010507)14:3<170:COHGFI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-SCATTER FACTOR; BLOOD-BRAIN-BARRIER; CENTRAL NERVOUS-SYSTEM; RECEPTOR C-MET; NEUROLOGICAL DISORDERS; NEUROTROPHIC FACTOR; CELL MOTILITY; IGG ANALYSES; EXPRESSION; PERMEABILITY;
Keywords:
blood-brain barrier; central nervous system; enzyme-linked immunosorbent assay; infection; neurotrophic factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Schirmacher, P Univ Cologne, Inst Pathol, Joseph Stelzmann Str 9, D-50931 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50931
Citazione:
M.A. Kern et al., "Concentrations of hepatocyte growth factor in cerebrospinal fluid under normal and different pathological conditions", CYTOKINE, 14(3), 2001, pp. 170-176

Abstract

Hepatocyte growth factor (HGF) and its specific receptor, MET, are expressed in the developing and adult mammalian brain. Recent studies have shown aneurotrophic activity of HGF in the nervous system. The present study focused on HGF concentrations in the cerebrospinal fluid (CSF) and serum in normal persons and in different central nervous system (CNS) diseases considering blood-CSF barrier (BCB) function. Concentrations of HGF were analyzed using an enzyme-linked immunosorbent assay (ELISA). HGF was present in normal human CSF (346 +/- 126 pg/ml) representing approximately half of the HGF serum concentrations. The CSF HGF levels were not significantly changed in chronic CNS disease and in aseptic meningitis (419 +/- pg/ml), but significantly increased in patients with bacterial meningitis (6101 +/- 5200 pg/ml). The HGF levels in CSF mere not influenced by increased serum concentrations in patients with normal or mildly affected BCB function. The results show that HGF is present in normal CSF and does not appear to cross the CSF barrier significantly unless it is severely disrupted. So far, strong increases of HGF concentration in CSF are only present in acute bacterial meningitis. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:26:08