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Titolo:
Neuregulin and ErbB receptor signaling pathways in the nervous system
Autore:
Buonanno, A; Fischbach, GD;
Indirizzi:
NIH, Sect Mol Neurobiol, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892NIH, Sect Mol Neurobiol, Bethesda, MD 20892 USA Columbia Univ Coll Phys & Surg, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
CURRENT OPINION IN NEUROBIOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 287 - 296
SICI:
0959-4388(200106)11:3<287:NAERSP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; NICOTINIC ACETYLCHOLINE-RECEPTOR; CEREBELLAR GRANULE CELLS; ETS TRANSCRIPTION FACTOR; EPSILON-SUBUNIT GENE; GA-BINDING-PROTEIN; SCHWANN-CELL; NEUROMUSCULAR-JUNCTION; IN-VIVO; POSTSYNAPTIC DENSITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Buonanno, A NIH, Sect Mol Neurobiol, Bldg 49,Room 5A-38, Bethesda, MD 20892 USA NIH Bldg 49,Room 5A-38 Bethesda MD USA 20892 sda, MD 20892 USA
Citazione:
A. Buonanno e G.D. Fischbach, "Neuregulin and ErbB receptor signaling pathways in the nervous system", CUR OP NEUR, 11(3), 2001, pp. 287-296

Abstract

The neuregulins are a complex family of factors that perform many functions during neural development. Recent experiments have shown that neuregulinspromote neuronal migration and differentiation, and regulate the selectiveexpression of neurotransmitter receptors in neurons and at the neuromuscular junction. They also regulate glial commitment, proliferation, survival and differentiation. At interneuronal synapses, neuregulin ErbB receptors associate with PDZ- domain proteins at postsynaptic densities where they can modulate synaptic plasticity. How this combinatorial network comprising many neuregulin ligands that signal through distinct combinations of dimeric ErbB receptors - elicits its multitude of biological effects is beginning tobe resolved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:29:37