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Titolo:
Trk receptors: mediators of neurotrophin action
Autore:
Patapoutin, A; Reichardt, LF;
Indirizzi:
Scripps Clin & Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Novartis Res Fdn, Genomics Inst, La Jolla, CA 92037 USA Novartis Res Fdn La Jolla CA USA 92037 omics Inst, La Jolla, CA 92037 USA Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
CURRENT OPINION IN NEUROBIOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 272 - 280
SICI:
0959-4388(200106)11:3<272:TRMONA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; SHP-2 TYROSINE PHOSPHATASE; ACTIVATED PROTEIN-KINASE; SIGNAL-REGULATED KINASE; SYMPATHETIC NEURONS; CELL-SURVIVAL; SENSORY NEURONS; PHOSPHATIDYLINOSITOL 3-KINASE; FUNCTIONALLY DISTINCT; DEPENDENT ACTIVATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Patapoutin, A Scripps Clin & Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 CA 92037 USA
Citazione:
A. Patapoutin e L.F. Reichardt, "Trk receptors: mediators of neurotrophin action", CUR OP NEUR, 11(3), 2001, pp. 272-280

Abstract

The four mammalian neurotrophins - NGF, BDNF, NT- and NT-4 - each bind andactivate one or more of the Trk family of receptor tyrosine kinases. Through these receptors, neurotrophins activate many intracellular signaling pathways, including those controlled by Ras, the Cdc42/Rac/RhoG protein family, MAPK, P13K and PLC-gamma, thereby affecting both development and functionof the nervous system. During the past two years, several novel signaling pathways controlled by Trk receptors have been characterized, and it has become clear that membrane transport and sorting controls Trk-receptor-mediated signaling because key intermediates are localized to different membrane compartments. Three-dimensional structures of the Trk receptors, in one instance in association with a neurotrophin, have revealed the structural bases underlying specificity in neurotrophin signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:52:03